Info
| ID | 2818 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 4m |
| SMILES | CCN(CC)C(=S)NC(=O)c1ccco1.Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H43N2O2PRuS/(1-46)(2-49)(3-50)(4-63)(5-46)(6-55)(7-56)(8-58)(9-60)(10-61)(11-57)(12-59)(13-64)(14-44)(15-44)(16-52)(17-75)(18-44)(19-53)(20-46)(21-72)(22-51)(23-54)(24-45)(25-48)(26-65)(27-67)(28-62)(29-48)(30-66)(31-69)(32-48)(33-68)(34-45)(35-45)(36-73)(37-47)(38-73)(39-74)(40-47)(41-74)(42-47)(43-82)(44-71)(45-73)(46-72)(47-74)(48-72)(49-50)(49-55)(50-56)(51-54)(51-75)(52-53)(52-71)(53-70)(54-76)(55-78)(56-57)(57-78)(58-59)(58-63)(59-79)(60-63)(60-64)(61-65)(61-66)(62-66)(62-67)(64-79)(65-80)(67-80)(68-69)(68-70)(69-71)(70-72)(73-83)(74-83)(75-85)(76-77)(76-85)(77-82)(77-84)(78-86)(79-86)(80-86)(81-82)(81-83)(81-87)(85-88)(86-88)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.56 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 0.69 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.1 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 4.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 5.7 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»