Info
| ID | 2817 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 3m |
| SMILES | CN(C)C(=S)NC(=O)c1ccco1.Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H39N2O2PRuS/(1-43)(2-44)(3-55)(4-47)(5-48)(6-50)(7-52)(8-53)(9-49)(10-51)(11-56)(12-45)(13-40)(14-40)(15-40)(16-66)(17-69)(18-46)(19-41)(20-41)(21-41)(22-60)(23-63)(24-67)(25-42)(26-57)(27-59)(28-54)(29-42)(30-58)(31-62)(32-42)(33-61)(34-67)(35-67)(36-68)(37-68)(38-68)(39-76)(40-65)(41-66)(42-66)(43-44)(43-47)(44-48)(45-46)(45-65)(46-64)(47-72)(48-49)(49-72)(50-51)(50-55)(51-73)(52-55)(52-56)(53-57)(53-58)(54-58)(54-59)(56-73)(57-74)(59-74)(60-63)(60-69)(61-62)(61-64)(62-65)(63-70)(64-66)(67-77)(68-77)(69-79)(70-71)(70-79)(71-76)(71-78)(72-80)(73-80)(74-80)(75-76)(75-77)(75-81)(79-82)(80-82)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 1.8 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 2.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 5.7 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 6 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»