Info
| ID | 2816 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 2m |
| SMILES | CCN(CC)C(=S)NC(=O)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C40ClN2OPRuS/(1-34)(2-35)(3-32)(4-30)(5-30)(6-7)(6-12)(7-37)(8-9)(8-12)(9-37)(10-11)(10-38)(11-19)(13-15)(13-19)(14-16)(14-31)(15-38)(16-32)(17-21)(17-39)(18-25)(18-33)(20-22)(20-39)(21-27)(22-27)(23-26)(23-32)(24-25)(24-29)(26-31)(28-29)(28-33)(30-31)(33-36)(34-42)(35-42)(36-41)(36-43)(37-44)(38-44)(39-44)(40-41)(40-42)(40-45)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.62 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MDA-MB-231 | 0.74 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 0.94 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 3.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 3.9 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»