Info
| ID | 2815 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 1m |
| SMILES | CN(C)C(=S)NC(=O)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38ClN2OPRuS/(1-30)(2-28)(3-28)(4-5)(4-10)(5-35)(6-7)(6-10)(7-35)(8-9)(8-36)(9-17)(11-13)(11-17)(12-14)(12-29)(13-36)(14-30)(15-19)(15-37)(16-23)(16-31)(18-20)(18-37)(19-25)(20-25)(21-24)(21-30)(22-23)(22-27)(24-29)(26-27)(26-31)(28-29)(31-34)(32-40)(33-40)(34-39)(34-41)(35-42)(36-42)(37-42)(38-39)(38-40)(38-43)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.73 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 1.4 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.6 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 4.2 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 5.6 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»