home← all complexes Ir builderC^N familiesD-MPNN

Complex #28 — Ru(2) [RAPTA-C]

2D Structure

Structure
⬇ MOL V3000

Info

ID28
MetalRu
Oxidation state2
Charge0
Donor atoms{"N": 3, "P": 1}
AbbreviationRAPTA-C
SMILESC1N2CN3CN1CP(C2)C3.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-]

TUCAN

C16Cl2N3PRu/(1-9)(2-8)(3-9)(4-5)(4-8)(5-10)(6-7)(6-10)(7-8)(9-10)(11-17)(11-18)(12-17)(12-19)(13-18)(13-19)(14-17)(14-20)(15-18)(15-20)(16-19)(16-20)

Measurements (56)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
Caco-212— 10.1039/c9dt00921c 2019
HeLa16— 10.1039/c9dt00921c 2019
HEK29355— 10.1039/c9dt00921c 2019
MCF-757— 10.1039/d3dt02037a 2023
CH-165— 10.1039/c1cc14713g 2012
MDA-MB-23171— 10.1039/d3dt02037a 2023
L-92984— 10.1039/d3dt02037a 2023
SW4801.7e+02— 10.1039/c1cc14713g 2012
A27802.3e+02— 10.1021/acs.inorgchem.7b00915 2017
A27802.3e+02— 10.1021/om3007079 2012
A27802.5e+02— 10.1038/ncomms4462 2014
A27802.5e+02— 10.1021/jm5002748 2014
A2780cisR2.7e+02— 10.1021/acs.inorgchem.7b00915 2017
A2780cisR2.7e+02— 10.1021/om3007079 2012
A27803.4e+02— 10.1016/j.jinorgbio.2013.10.01... 2014
A27803.5e+02— 10.1021/om800899e 2009
A27803.5e+02— 10.1021/om900345n 2009
HT-294.4e+02— 10.1021/ic061008y 2006
A2780cisR5.1e+02— 10.1038/ncomms4462 2014
A5491e+03— 10.1021/ic061008y 2006
T47D1.1e+03— 10.1021/ic061008y 2006
TS/A—— 10.1021/jm050015d 2005
HBL-100—— 10.1021/jm050015d 2005
COV362—— 10.3389/fphar.2022.920379 2022
A2780—— 10.1039/d1dt03274g 2021
A2780cisR—— 10.1039/d1dt03274g 2021
HEK293T—— 10.1039/d1dt03274g 2021
A2780—— 10.1002/aoc.6550 2021
HEK293—— 10.1002/aoc.6550 2021
HEK293—— 10.1021/acs.inorgchem.7b00915 2017
A2780—— 10.1021/acs.inorgchem.7b01082 2017
A2780cisR—— 10.1021/acs.inorgchem.7b01082 2017
HEK293—— 10.1021/acs.inorgchem.7b01082 2017
BALB/3T3 clone A31—— 10.1039/c7nj02300f 2017
MCF-7—— 10.2174/1871520616666160404110... 2017
HCC1937—— 10.2174/1871520616666160404110... 2017
A2780—— 10.1039/c8dt01555d 2018
A2780cisR—— 10.1039/c8dt01555d 2018
HEK293—— 10.1039/c8dt01555d 2018
HCT-116—— 10.1002/elps.201700443 2018
HEK293—— 10.1021/om3007079 2012
A549—— 10.1039/c1cc14713g 2012
A549—— 10.1016/j.jinorgbio.2013.10.01... 2014
HCT-116—— 10.1016/j.jinorgbio.2013.10.01... 2014
HCC1937—— 10.1016/j.jinorgbio.2013.10.01... 2014
MRC-5—— 10.1016/j.jinorgbio.2013.10.01... 2014
MCF-7—— 10.1021/ic061008y 2006
A2780—— 10.1002/cmdc.200700209 2007
A2780cisR—— 10.1002/cmdc.200700209 2007
A2780—— 10.1021/ic701474m 2007
A549—— 10.1021/jm070039f 2007
HT-29—— 10.1021/jm070039f 2007
T47D—— 10.1021/jm070039f 2007
TS/A—— 10.1021/jm070039f 2007
HBL-100—— 10.1021/jm070039f 2007
HEK293—— 10.1021/jm5002748 2014

🧬 Cell Death Types (1)

Apoptosis high
«RAED-C and RAPTA-C appearing to induce a faster apoptotic response (Fig. 6a and Supplementary Data 1A–D).»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.