Info
| ID | 2753 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 2, "N": 2} |
| Abbreviation | [Ru(quin)2] |
| SMILES | [O-]c1cccc2cccnc12.[O-]c1cccc2cccnc12 |
TUCAN
C18H12N2O2Ru/(1-25)(2-16)(3-13)(4-17)(5-14)(6-15)(7-19)(8-20)(9-18)(10-22)(11-26)(12-21)(13-16)(13-23)(14-17)(14-23)(15-16)(15-29)(17-25)(18-20)(18-21)(19-22)(19-26)(20-30)(21-24)(22-24)(23-27)(24-28)(25-31)(26-32)(27-29)(27-31)(28-30)(28-32)(29-33)(30-34)(31-35)(32-35)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 46 | — | 10.3390/cancers17020195 | 2025 |
| T47D | 48 | — | 10.3390/cancers17020195 | 2025 |
🧬 Cell Death Types (2)
Apoptosis
high
«Ru(quin)2 treatment significantly increased caspase-3 activity in both T47D and MDA-MB-231 cells compared to untreated controls after 24 h (Figure 2B). Additionally, ... Ru(quin)2 treatment significan...»
Autophagy
high
«Immunoblot analysis revealed that Ru(quin)2 treatment increased the conversion of soluble LC3-I to lipid-bound LC3-II in a dose-dependent manner, indicating the induction of autophagy (Figure 3A,B). ....»