Info
| ID | 2734 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "O": 1} |
| Abbreviation | Ru-1 |
| SMILES | C=CC1=C(C)c2cc3[n-]c(cc4nc(cc5[n-]c(cc1n2)c(C)c5CCC(=O)OC)C(CCC(=O)OC)=C4C)c(C)c3C=C.[C-]#[O+] |
TUCAN
C37H36N4O5Ru/(1-42)(2-47)(3-51)(4-38)(5-49)(6-40)(7-50)(8-41)(9-50)(10-40)(11-49)(12-44)(13-71)(14-40)(15-71)(16-38)(17-71)(18-39)(19-46)(20-52)(21-41)(22-45)(23-39)(24-37)(25-70)(26-51)(27-41)(28-48)(29-39)(30-37)(31-70)(32-42)(33-42)(34-52)(35-70)(36-43)(37-43)(38-44)(39-55)(40-53)(41-59)(42-56)(43-54)(44-60)(45-61)(45-64)(46-62)(46-68)(47-65)(47-66)(48-63)(48-67)(49-50)(49-73)(50-58)(51-52)(51-72)(52-57)(53-54)(53-63)(54-64)(55-58)(55-67)(56-57)(56-68)(57-65)(58-66)(59-60)(59-61)(60-62)(61-75)(62-75)(63-76)(64-76)(65-74)(66-77)(67-77)(68-74)(69-78)(70-82)(71-81)(72-79)(72-81)(73-80)(73-82)(76-83)(77-83)(81-83)(82-83)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| AGS | 95 | 3.8 | 10.1021/acs.inorgchem.5c00896 | 2025 |
🧬 Cell Death Types (3)
Apoptosis
high
«Figure 11 shows that, except for PpIX, all compounds induced the cleavage of caspase 3 and PARP after irradiation ... All compounds, except for PpIX, induced the expression of CHOP upon irradiation.»
Autophagy
high
«The results show that following irradiation, all ruthenium compounds induced the expression of LC3B–I and LC3B–II»
Ferroptosis
medium
«This showed that upon activation by light, PpIX and Ru-3B lead to a decrease in GPX4 expression (Figure 12a,b), which suggests that these two compounds might induce ferroptosis.»