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Complex #2699 — Ru(2) [4]

2D Structure

Structure
⬇ MOL V3000

Info

ID2699
MetalRu
Oxidation state2
Charge1
Donor atoms{"O": 1, "N": 3, "P": 2}
Abbreviation4
SMILESO=C([O-])c1ccccn1.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1

TUCAN

C43H38N3O2P2Ru/(1-41)(2-39)(3-40)(4-44)(5-76)(6-46)(7-47)(8-45)(9-68)(10-48)(11-54)(12-76)(13-69)(14-71)(15-77)(16-55)(17-56)(18-57)(19-68)(20-60)(21-62)(22-59)(23-63)(24-58)(25-61)(26-65)(27-66)(28-77)(29-51)(30-42)(31-50)(32-49)(33-52)(34-64)(35-70)(36-43)(37-67)(38-53)(39-41)(39-44)(40-44)(40-45)(41-78)(42-50)(42-69)(43-49)(43-70)(45-78)(46-47)(46-54)(47-48)(48-79)(49-52)(50-51)(51-72)(52-74)(53-64)(53-73)(54-55)(55-79)(56-57)(56-59)(57-80)(58-59)(58-60)(60-80)(61-62)(61-63)(62-81)(63-66)(64-67)(65-66)(65-81)(67-71)(68-76)(68-77)(69-82)(70-84)(71-83)(72-73)(72-82)(73-83)(74-75)(74-84)(75-85)(75-86)(76-87)(77-88)(78-87)(79-87)(80-88)(81-88)(82-89)(83-89)(84-89)(87-89)(88-89)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MRC-51.5 10.1007/s10534-017-0006-1 2017
T98G1.5 10.1007/s10534-017-0006-1 2017
MDA-MB-2313.3 10.21577/0103-5053.20200020 2020
U-87 MG4.9 10.1007/s10534-017-0006-1 2017
S18011 10.21577/0103-5053.20200020 2020

🧬 Cell Death Types (2)

Apoptosis high
«The phosphine ruthenium II complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion.»
Autophagy high
«The phosphine ruthenium II complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion.»