Info
| ID | 2698 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 3, "P": 2} |
| Abbreviation | 2 |
| SMILES | O=C([O-])c1ccccn1.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C42H36N3O2P2Ru/(1-38)(2-42)(3-44)(4-37)(5-73)(6-50)(7-66)(8-51)(9-41)(10-73)(11-43)(12-53)(13-74)(14-46)(15-39)(16-74)(17-52)(18-57)(19-54)(20-55)(21-59)(22-56)(23-58)(24-60)(25-63)(26-64)(27-62)(28-47)(29-68)(30-45)(31-48)(32-61)(33-67)(34-40)(35-65)(36-49)(37-42)(37-44)(38-42)(38-75)(39-46)(39-66)(40-45)(40-67)(41-44)(41-75)(43-51)(43-76)(45-48)(46-47)(47-69)(48-71)(49-61)(49-70)(50-51)(50-53)(52-53)(52-76)(54-57)(54-77)(55-58)(55-77)(56-57)(56-58)(59-60)(59-78)(60-64)(61-65)(62-63)(62-78)(63-64)(65-68)(66-79)(67-81)(68-80)(69-70)(69-79)(70-80)(71-72)(71-81)(72-82)(72-83)(73-74)(73-84)(74-85)(75-84)(76-84)(77-85)(78-85)(79-86)(80-86)(81-86)(84-86)(85-86)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 7.6 | — | 10.21577/0103-5053.20200020 | 2020 |
| T98G | 19 | — | 10.1007/s10534-017-0006-1 | 2017 |
| U-87 MG | 28 | — | 10.1007/s10534-017-0006-1 | 2017 |
| S180 | 31 | — | 10.21577/0103-5053.20200020 | 2020 |
| MRC-5 | 82 | — | 10.1007/s10534-017-0006-1 | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The phosphine ruthenium II complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion.»
Autophagy
high
«The phosphine ruthenium II complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion.»