Info
| ID | 2676 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Δ-[Ru(bpy)2PBIP]2+ |
| SMILES | Brc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C39H27BrN8Ru/(1-51)(2-39)(3-28)(4-52)(5-31)(6-29)(7-33)(8-34)(9-30)(10-32)(11-37)(12-47)(13-46)(14-38)(15-56)(16-53)(17-36)(18-35)(19-54)(20-40)(21-55)(22-45)(23-43)(24-44)(25-41)(26-42)(27-68)(28-31)(28-60)(29-31)(29-51)(30-35)(30-52)(32-43)(32-53)(33-35)(33-61)(34-38)(34-48)(36-43)(36-62)(37-39)(37-50)(38-56)(39-66)(40-47)(40-66)(41-44)(41-63)(42-44)(42-54)(45-46)(45-55)(46-49)(47-50)(48-59)(48-64)(49-57)(49-58)(50-65)(51-69)(52-70)(53-71)(54-73)(55-74)(56-67)(57-59)(57-72)(58-64)(58-74)(59-68)(60-61)(60-69)(61-70)(62-63)(62-71)(63-73)(64-67)(65-68)(65-72)(66-75)(69-76)(70-76)(71-76)(72-76)(73-76)(74-76)
Measurements (17)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 2.8 | — | 10.1039/d3dt01584j | 2023 |
| PC-3 | 3.5 | — | 10.1039/d3dt01584j | 2023 |
| A2780 | 5.6 | — | 10.1039/d3dt01584j | 2023 |
| A2780 | 6.2 | — | 10.1039/d3dt01584j | 2023 |
| HeLa | 18 | — | 10.1039/d3dt01584j | 2023 |
| A375 | 21 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| HeLa | 27 | — | 10.1039/d3dt01584j | 2023 |
| Ect1/E6E7 | 39 | — | 10.1039/d3dt01584j | 2023 |
| BEAS-2B | 39 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| Ect1/E6E7 | 50 | — | 10.1039/d3dt01584j | 2023 |
| A375 | 73 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| HeLa | 1e+02 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| A549 | 1.4e+02 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| BEAS-2B | 1.4e+02 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| HeLa | 2e+02 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| A549 | 2.3e+02 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
| MCF-7 | 2.8e+02 | — | 10.1016/j.jinorgbio.2018.01.01... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometry experiments showed that the apoptosis was enhanced by increasing the concentration of each enantiomer. Western blotting analyses indicated that both extrinsic and intrinsic apoptosis pa...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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