Info
| ID | 2672 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | 8a |
| SMILES | O=C1CCN(Cc2cc3cccnc3c3ncccc23)CC1.c1ccc2nc(-c3ccc4ccccc4n3)ccc2c1.c1ccc2nc(-c3ccc4ccccc4n3)ccc2c1 |
TUCAN
C54H41N7ORu/(1-47)(2-48)(3-46)(4-42)(5-44)(6-49)(7-45)(8-59)(9-43)(10-64)(11-55)(12-80)(13-81)(14-71)(15-71)(16-53)(17-52)(18-82)(19-82)(20-60)(21-70)(22-51)(23-56)(24-69)(25-54)(26-65)(27-62)(28-58)(29-72)(30-61)(31-83)(32-84)(33-63)(34-66)(35-50)(36-68)(37-57)(38-67)(39-72)(40-83)(41-84)(42-44)(42-47)(43-45)(43-49)(44-59)(45-64)(46-48)(46-73)(47-73)(48-85)(49-75)(50-51)(50-66)(51-55)(52-53)(52-74)(53-80)(54-56)(54-87)(55-76)(56-76)(57-67)(57-69)(58-62)(58-75)(59-86)(60-70)(60-81)(61-77)(61-79)(62-88)(63-68)(63-78)(64-89)(65-69)(65-78)(66-90)(67-92)(68-91)(70-79)(71-82)(71-95)(72-83)(72-95)(73-86)(74-77)(74-94)(75-89)(76-90)(77-84)(78-92)(79-93)(80-101)(81-97)(82-96)(83-96)(84-96)(85-87)(85-98)(86-98)(87-100)(88-91)(88-99)(89-99)(90-100)(91-102)(92-102)(93-94)(93-97)(94-101)(95-103)(97-104)(98-104)(99-104)(100-104)(101-104)(102-104)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | 32 | 10.1021/acs.molpharmaceut.4c01... | 2025 |
| 4T1 | — | 91 | 10.1021/acs.molpharmaceut.4c01... | 2025 |
🧬 Cell Death Types (1)
Immunogenic Cell Death
high
«Furthermore, 8b also initiated an ICD cascade, enhancing recruitment and maturation of antigen-presenting cells, thus triggering a CD8+ T cell antitumor immune response.»