Info
| ID | 2654 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | POW-12A |
| SMILES | c1cnc2c(c1)c1ncc3c(c1c1cccnc12)CCCC3.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C43H31N7Ru/(1-36)(2-32)(3-61)(4-33)(5-62)(6-34)(7-65)(8-64)(9-51)(10-46)(11-67)(12-47)(13-66)(14-37)(15-35)(16-49)(17-49)(18-38)(19-39)(20-51)(21-63)(22-41)(23-40)(24-48)(25-50)(26-50)(27-45)(28-48)(29-44)(30-42)(31-43)(32-33)(32-52)(33-61)(34-35)(34-62)(35-53)(36-38)(36-52)(37-41)(37-65)(38-53)(39-45)(39-66)(40-44)(40-56)(41-56)(42-43)(42-63)(43-58)(44-57)(45-57)(46-47)(46-59)(47-67)(48-49)(48-54)(49-50)(50-51)(51-55)(52-68)(53-69)(54-55)(54-64)(55-60)(56-71)(57-74)(58-60)(58-70)(59-72)(59-73)(60-72)(61-76)(62-77)(63-75)(64-80)(65-78)(66-81)(67-79)(68-69)(68-76)(69-77)(70-73)(70-75)(71-74)(71-78)(72-80)(73-79)(74-81)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 12 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| DU-145 | 35 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| A2780-CP70 | 35 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| HeLa | 63 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| PNT1A | — | — | 10.3389/fmolb.2023.1252285 | 2023 |
| MDA-MB-231 | — | — | 10.3389/fmolb.2023.1252285 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«An increase in Q4 (annexin V APC), demonstrating early apoptosis, was seen for both VNK-572 and cisplatin following 72 h of treatment (14% vs. 26% for VNK-572% and 13% vs. 39% for cisplatin). The same...»