Info
| ID | 2653 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | VNK-572 |
| SMILES | c1cnc2c(c1)c1ncc3c(c1c1cccnc12)CCC3.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C42H29N7Ru/(1-34)(2-33)(3-58)(4-30)(5-59)(6-31)(7-62)(8-44)(9-47)(10-64)(11-45)(12-63)(13-32)(14-35)(15-48)(16-46)(17-37)(18-42)(19-60)(20-39)(21-36)(22-41)(23-46)(24-47)(25-38)(26-48)(27-43)(28-40)(29-61)(30-33)(30-58)(31-36)(31-59)(32-35)(32-62)(33-49)(34-37)(34-49)(35-50)(36-53)(37-50)(38-42)(38-54)(39-40)(39-60)(40-55)(41-43)(41-53)(42-63)(43-54)(44-45)(44-56)(45-64)(46-47)(46-48)(47-52)(48-51)(49-65)(50-66)(51-52)(51-61)(52-57)(53-68)(54-71)(55-57)(55-67)(56-69)(56-70)(57-69)(58-73)(59-74)(60-72)(61-77)(62-75)(63-78)(64-76)(65-66)(65-73)(66-75)(67-70)(67-72)(68-71)(68-74)(69-77)(70-76)(71-78)(73-79)(74-79)(75-79)(76-79)(77-79)(78-79)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 10 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| A2780-CP70 | 15 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| DU-145 | 19 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| HeLa | 52 | — | 10.3389/fmolb.2023.1252285 | 2023 |
| PNT1A | — | — | 10.3389/fmolb.2023.1252285 | 2023 |
| MDA-MB-231 | — | — | 10.3389/fmolb.2023.1252285 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«An increase in Q4 (annexin V APC), demonstrating early apoptosis, was seen for both VNK-572 and cisplatin following 72 h of treatment (14% vs. 26% for VNK-572% and 13% vs. 39% for cisplatin). The same...»