Info
| ID | 2636 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 1} |
| Abbreviation | 2 |
| SMILES | COc1cc(/N=C/c2c([O-])ccc3ccccc23)cc(OC)c1OC.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C30H32NO4Ru/(1-36)(2-38)(3-33)(4-34)(5-33)(6-34)(7-53)(8-33)(9-56)(10-58)(11-46)(12-39)(13-56)(14-35)(15-35)(16-34)(17-35)(18-37)(19-44)(20-47)(21-42)(22-54)(23-57)(24-45)(25-57)(26-57)(27-41)(28-58)(29-43)(30-40)(31-56)(32-58)(33-53)(34-48)(35-53)(36-38)(36-49)(37-44)(37-49)(38-48)(39-55)(39-60)(40-41)(40-43)(41-50)(42-47)(42-62)(43-46)(44-48)(45-55)(45-61)(46-51)(47-50)(49-53)(50-51)(51-52)(52-54)(52-62)(54-63)(55-63)(56-66)(57-67)(58-65)(59-60)(59-61)(59-66)(60-65)(61-67)(62-64)(63-68)(67-68)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 5.5 | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| MIA PaCa-2 | 6.1 | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| HepG2 | 7.5 | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| HFF-1 | 7.7 | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| HEK293 | 8.7 | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Cellular studies show that all of the N,O-coordinated complexes (1–3) initiate disruption of the microtubule network in MDA-MB-231 cells in a dose-dependent manner within 6 h of incubation and finally...»