Info
| ID | 258 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | [7]NO3 |
| SMILES | COC(=O)c1ccnc(-c2cc(C(=O)OC)ccn2)c1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C24H26N2O4Ru/(1-42)(2-31)(3-27)(4-27)(5-28)(6-27)(7-35)(8-28)(9-29)(10-29)(11-30)(12-32)(13-28)(14-29)(15-33)(16-43)(17-34)(18-47)(19-47)(20-47)(21-48)(22-44)(23-48)(24-48)(25-36)(26-37)(27-42)(28-38)(29-42)(30-31)(30-39)(31-38)(32-35)(32-39)(33-40)(33-45)(34-40)(34-43)(35-38)(36-41)(36-46)(37-41)(37-44)(39-42)(40-49)(41-50)(43-51)(44-52)(45-46)(45-51)(46-52)(47-55)(48-56)(49-53)(49-55)(50-54)(50-56)(51-57)(52-57)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 21 | — | 10.3390/ijms241511896 | 2023 |
| EA.hy926 | 31 | — | 10.3390/ijms241511896 | 2023 |
| Vero | 46 | — | 10.3390/ijms241511896 | 2023 |
| HeLa | 2.2e+02 | — | 10.1021/acs.inorgchem.1c00641 | 2021 |
| MCF-7 | 3.1e+02 | — | 10.1021/acs.inorgchem.1c00641 | 2021 |
| A2780 | — | — | 10.1021/acs.inorgchem.1c00641 | 2021 |
| A2780cisR | — | — | 10.1021/acs.inorgchem.1c00641 | 2021 |
| HEK293 | — | — | 10.1021/acs.inorgchem.1c00641 | 2021 |
| MCF-10A | — | — | 10.3390/ijms241511896 | 2023 |
| HepG2 | — | — | 10.3390/ijms241511896 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence imaging and flow cytometry analysis demonstrate that 1 and 2 effectively penetrate the membrane and promote T24 cell death through the apoptotic pathway, mainly inducing early apoptosis o...»