Info
| ID | 2564 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 3, "P": 2} |
| Abbreviation | SCAR1 |
| SMILES | O=C([O-])c1ccccn1.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C44H40N3O2P2Ru/(1-41)(2-43)(3-48)(4-42)(5-79)(6-50)(7-49)(8-46)(9-70)(10-47)(11-58)(12-79)(13-70)(14-51)(15-61)(16-59)(17-71)(18-71)(19-60)(20-62)(21-57)(22-63)(23-65)(24-66)(25-67)(26-80)(27-64)(28-80)(29-54)(30-72)(31-74)(32-44)(33-53)(34-52)(35-55)(36-68)(37-73)(38-45)(39-69)(40-56)(41-43)(41-81)(42-43)(42-48)(44-53)(44-72)(45-52)(45-73)(46-48)(46-81)(47-49)(47-82)(49-50)(50-58)(51-58)(51-82)(52-55)(53-54)(54-75)(55-77)(56-68)(56-76)(57-61)(57-63)(59-61)(59-83)(60-63)(60-83)(62-66)(62-84)(64-67)(64-84)(65-66)(65-67)(68-69)(69-74)(70-71)(70-79)(71-80)(72-85)(73-87)(74-86)(75-76)(75-85)(76-86)(77-78)(77-87)(78-88)(78-89)(79-90)(80-91)(81-90)(82-90)(83-91)(84-91)(85-92)(86-92)(87-92)(90-92)(91-92)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 3.6 | — | 10.1039/c8qi00941d | 2019 |
| MDA-MB-231 | 4.2 | — | 10.1039/c8qi00941d | 2019 |
| T98G | 12 | — | 10.1007/s10534-017-0006-1 | 2017 |
| U-87 MG | 16 | — | 10.1007/s10534-017-0006-1 | 2017 |
| A549 | 22 | — | 10.1039/c8qi00941d | 2019 |
| V79 | 33 | — | 10.1039/c8qi00941d | 2019 |
| MRC-5 | 41 | — | 10.1007/s10534-017-0006-1 | 2017 |
| Vero | 48 | — | 10.3390/molecules19055999 | 2014 |
🧬 Cell Death Types (2)
Apoptosis
high
«The phosphine ruthenium II complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion.»
Autophagy
high
«The phosphine ruthenium II complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion.»