Info
| ID | 254 |
| Metal | Ru |
| Oxidation state | 3 |
| Charge | -1 |
| Donor atoms | {"S": 1, "O": 1, "N": 1} |
| Abbreviation | AziRu |
| SMILES | CS(C)=O.[Cl-].[Cl-].[Cl-].[Cl-].c1ccncc1 |
TUCAN
C7H11NORuS/(1-13)(2-14)(3-12)(4-15)(5-17)(6-17)(7-17)(8-18)(9-18)(10-16)(11-18)(12-13)(12-14)(13-15)(14-16)(15-19)(16-19)(17-21)(18-21)(19-22)(20-21)(21-22)
Measurements (18)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 3e+02 | — | 10.1039/c4tb01807a | 2015 |
| MCF-7 | 3e+02 | — | 10.1021/bm400104b | 2013 |
| C6 | 3.2e+02 | — | 10.1021/bm400104b | 2013 |
| HeLa | 3.8e+02 | — | 10.1039/c4tb01807a | 2015 |
| WiDr | 4.4e+02 | — | 10.1021/bm400104b | 2013 |
| WiDr | 5.2e+02 | — | 10.1039/c4tb01807a | 2015 |
| MCF-7 | — | — | 10.1038/srep45236 | 2017 |
| MDA-MB-231 | — | — | 10.1038/srep45236 | 2017 |
| MDA-MB-436 | — | — | 10.1038/srep45236 | 2017 |
| MDA-MB-468 | — | — | 10.1038/srep45236 | 2017 |
| CG-5 | — | — | 10.1038/srep45236 | 2017 |
| HaCaT | — | — | 10.1039/c4tb01807a | 2015 |
| L6 | — | — | 10.1039/c4tb01807a | 2015 |
| MCF-7 | — | — | 10.1016/j.bioadv.2022.213016 | 2022 |
| MDA-MB-231 | — | — | 10.1016/j.bioadv.2022.213016 | 2022 |
| A375 | — | — | 10.1016/j.bioadv.2022.213016 | 2022 |
| HCT-116 | — | — | 10.1016/j.bioadv.2022.213016 | 2022 |
| HaCaT | — | — | 10.1016/j.bioadv.2022.213016 | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«the most efficient ruthenium-containing cationic nanoaggregates we have hitherto developed are able to elicit both extrinsic and intrinsic apoptosis, as well as autophagy.»
Autophagy
high
«the cationic DoHuRu/DOTAP formulation induced an evident increase in the Mean Fluorescence Intensity (MFI), in particular 4.3 and 5.8-fold higher at 48 and 72 h for MCF-7, and 3.9 and 5.3-fold higher ...»