Info
| ID | 252 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(-c2ccc(C)cn2)nc1.c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1 |
TUCAN
C50H36N10Ru/(1-48)(2-42)(3-73)(4-50)(5-53)(6-46)(7-55)(8-39)(9-40)(10-47)(11-74)(12-69)(13-60)(14-37)(15-44)(16-70)(17-37)(18-37)(19-52)(20-49)(21-43)(22-54)(23-51)(24-45)(25-59)(26-71)(27-56)(28-57)(29-41)(30-38)(31-72)(32-38)(33-38)(34-58)(35-89)(36-90)(37-63)(38-68)(39-42)(39-46)(40-50)(40-61)(41-44)(41-77)(42-48)(43-55)(43-57)(44-63)(45-51)(45-62)(46-49)(47-53)(47-64)(48-65)(49-65)(50-73)(51-74)(52-58)(52-68)(53-69)(54-55)(54-66)(56-60)(56-71)(57-59)(58-78)(59-66)(60-67)(61-75)(61-80)(62-83)(62-84)(63-70)(64-76)(64-79)(65-85)(66-86)(67-81)(67-82)(68-72)(69-91)(70-93)(71-92)(72-94)(73-87)(74-88)(75-79)(75-89)(76-80)(76-91)(77-78)(77-93)(78-94)(79-95)(80-87)(81-83)(81-96)(82-84)(82-92)(83-90)(84-88)(85-89)(85-95)(86-90)(86-96)(91-97)(92-97)(93-97)(94-97)(95-97)(96-97)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 9.9 | — | 10.1021/jacs.2c11111 | 2023 |
| HCC38 | 16 | — | 10.1021/jacs.2c11111 | 2023 |
| MDA-MB-231 | 20 | — | 10.1021/jacs.2c11111 | 2023 |
| T24 | 30 | — | 10.1021/jacs.2c11111 | 2023 |
| MCF-10A | 63 | — | 10.1021/jacs.2c11111 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Examining cell fate, an increase in cells with sub-G1 DNA content and annexin V positive population indicate the induction of apoptosis by 4»