Info
| ID | 2519 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | P5 |
| SMILES | CCCCCCCCC(=O)NC(=S)Nc1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C26Cl2N2ORuS/(1-22)(2-22)(3-19)(4-23)(5-6)(5-18)(6-7)(7-8)(8-14)(9-13)(9-16)(10-12)(10-21)(11-20)(11-21)(12-23)(13-15)(14-25)(15-17)(16-24)(17-24)(18-19)(20-23)(21-22)(24-28)(25-27)(25-29)(26-27)(26-28)(26-30)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HUVEC | 6.5 | — | 10.1039/d1dt02611a | 2021 |
| A549 | 7.7 | — | 10.1039/d1dt02611a | 2021 |
| A549cisR | 13 | — | 10.1039/d1dt02611a | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Staining assays and flow cytometric analyses of P5 and P6 in A549 cells revealed that the complexes induced apoptosis and arrested the cell cycle predominantly in the S phase.»