Info
| ID | 2516 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | P2 |
| SMILES | CC(=O)NC(=S)Nc1cccc2ccccc12.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C23Cl2N2ORuS/(1-17)(2-17)(3-18)(4-22)(5-7)(5-16)(6-15)(6-16)(7-18)(8-11)(8-12)(9-10)(9-14)(10-21)(11-19)(12-13)(13-20)(14-19)(15-18)(16-17)(19-20)(20-21)(21-25)(22-24)(22-26)(23-24)(23-25)(23-27)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 13 | — | 10.1039/d1dt02611a | 2021 |
| HUVEC | 14 | — | 10.1039/d1dt02611a | 2021 |
| A549cisR | 28 | — | 10.1039/d1dt02611a | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Staining assays and flow cytometric analyses of P5 and P6 in A549 cells revealed that the complexes induced apoptosis and arrested the cell cycle predominantly in the S phase.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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