Info
| ID | 251 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(-c2ccc(C)cn2)nc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C48H32N10Ru/(1-36)(2-63)(3-46)(4-61)(5-51)(6-64)(7-62)(8-65)(9-35)(10-40)(11-43)(12-41)(13-42)(14-37)(15-45)(16-33)(17-33)(18-38)(19-39)(20-33)(21-50)(22-47)(23-66)(24-48)(25-49)(26-53)(27-54)(28-34)(29-34)(30-52)(31-34)(32-44)(33-57)(34-60)(35-46)(35-55)(36-47)(36-61)(37-51)(37-56)(38-39)(38-68)(39-57)(40-48)(40-76)(41-48)(41-50)(42-54)(42-77)(43-49)(43-66)(44-52)(44-60)(45-53)(45-54)(46-63)(47-58)(49-59)(50-74)(51-64)(52-69)(53-75)(55-70)(55-71)(56-72)(56-73)(57-62)(58-67)(58-78)(59-79)(59-80)(60-65)(61-81)(62-85)(63-87)(64-89)(65-90)(66-84)(67-71)(67-81)(68-69)(68-85)(69-90)(70-78)(70-86)(71-87)(72-79)(72-88)(73-80)(73-89)(74-76)(74-86)(75-77)(75-88)(76-82)(77-83)(78-82)(79-83)(80-84)(85-91)(86-91)(87-91)(88-91)(89-91)(90-91)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCC38 | 3.8 | — | 10.1021/jacs.2c11111 | 2023 |
| HCT-116 | 16 | — | 10.1021/jacs.2c11111 | 2023 |
| MDA-MB-231 | 22 | — | 10.1021/jacs.2c11111 | 2023 |
| T24 | 28 | — | 10.1021/jacs.2c11111 | 2023 |
| MCF-10A | — | — | 10.1021/jacs.2c11111 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Examining cell fate, an increase in cells with sub-G1 DNA content and annexin V positive population indicate the induction of apoptosis by 4»