Info
| ID | 250 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(-c2ccc(C)cn2)nc1.Cc1ccc(-c2ccc(C)cn2)nc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C42H34N8Ru/(1-41)(2-35)(3-65)(4-50)(5-35)(6-44)(7-35)(8-61)(9-62)(10-36)(11-51)(12-64)(13-36)(14-63)(15-66)(16-36)(17-37)(18-48)(19-39)(20-42)(21-37)(22-52)(23-40)(24-45)(25-47)(26-43)(27-49)(28-37)(29-38)(30-46)(31-38)(32-54)(33-53)(34-38)(35-55)(36-56)(37-58)(38-59)(39-40)(39-45)(40-48)(41-42)(41-55)(42-73)(43-44)(43-74)(44-58)(45-70)(46-47)(46-75)(47-56)(48-68)(49-51)(49-60)(50-52)(50-65)(51-64)(52-57)(53-54)(53-76)(54-59)(55-61)(56-62)(57-69)(57-71)(58-63)(59-66)(60-67)(60-72)(61-79)(62-81)(63-83)(64-82)(65-78)(66-84)(67-71)(67-80)(68-70)(68-77)(69-72)(69-78)(70-80)(71-77)(72-82)(73-74)(73-79)(74-83)(75-76)(75-81)(76-84)(79-85)(80-85)(81-85)(82-85)(83-85)(84-85)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 34 | — | 10.1021/jacs.2c11111 | 2023 |
| HCT-116 | 54 | — | 10.1021/jacs.2c11111 | 2023 |
| MDA-MB-231 | — | — | 10.1021/jacs.2c11111 | 2023 |
| HCC38 | — | — | 10.1021/jacs.2c11111 | 2023 |
| MCF-10A | — | — | 10.1021/jacs.2c11111 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Examining cell fate, an increase in cells with sub-G1 DNA content and annexin V positive population indicate the induction of apoptosis by 4»