Info
| ID | 248 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru3 |
| SMILES | c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C48H28N10Ru/(1-33)(2-32)(3-57)(4-34)(5-59)(6-31)(7-30)(8-58)(9-35)(10-50)(11-46)(12-61)(13-36)(14-37)(15-41)(16-40)(17-29)(18-42)(19-39)(20-43)(21-48)(22-47)(23-49)(24-45)(25-62)(26-38)(27-60)(28-44)(29-37)(29-53)(30-40)(30-54)(31-38)(31-53)(32-41)(32-69)(33-36)(33-61)(34-41)(34-42)(35-47)(35-70)(36-51)(37-57)(38-55)(39-45)(39-58)(40-59)(42-66)(43-49)(43-52)(44-50)(44-60)(45-55)(46-47)(46-48)(48-74)(49-62)(50-56)(51-68)(51-72)(52-71)(52-75)(53-63)(54-64)(54-67)(55-65)(56-73)(56-76)(57-81)(58-83)(59-84)(60-85)(61-77)(62-78)(63-65)(63-81)(64-72)(64-82)(65-83)(66-69)(66-82)(67-68)(67-84)(68-77)(69-79)(70-74)(70-80)(71-73)(71-78)(72-79)(73-85)(74-86)(75-76)(75-80)(76-86)(81-87)(82-87)(83-87)(84-87)(85-87)(86-87)
Measurements (16)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 36 | — | 10.1016/j.ica.2012.01.023 | 2012 |
| HepG2 | 41 | — | 10.1016/j.ica.2012.01.023 | 2012 |
| HLF | 45 | — | 10.1021/jacs.1c01424 | 2021 |
| HeLa | 45 | — | 10.1021/jacs.1c01424 | 2021 |
| A549 | 49 | — | 10.1021/jacs.1c01424 | 2021 |
| A549cisR | 58 | — | 10.1021/jacs.1c01424 | 2021 |
| MDA-MB-231 | 62 | — | 10.1021/jacs.1c01424 | 2021 |
| CT-26 | — | 7 | 10.1021/acs.inorgchem.3c02606 | 2023 |
| CT-26 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
| CT-26 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
| HT-29 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
| HT-29 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
| HT-29 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
| RPE-1 | — | 9 | 10.1021/acs.inorgchem.3c02606 | 2023 |
| RPE-1 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
| RPE-1 | — | — | 10.1021/acs.inorgchem.3c02606 | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«These results suggest that mitophagy and apoptosis are involved in Ru1-induced cell death.»
Autophagy
high
«Transmission electron microscopy shows that some of the mitochondria are enclosed in double-membrane structures after A549 cells are treated with Ru1 for 24 h, which indicates that mitochondria are de...»