Info
| ID | 247 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 3 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru2 |
| SMILES | O=C(NCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)c1cc2cccnc2c2ncccc12.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C67H53N9OPRu/(1-56)(2-99)(3-102)(4-70)(5-68)(6-67)(7-77)(8-117)(9-69)(10-76)(11-117)(12-79)(13-64)(14-81)(15-63)(16-59)(17-54)(18-55)(19-57)(20-80)(21-88)(22-89)(23-90)(24-88)(25-89)(26-91)(27-90)(28-83)(29-78)(30-74)(31-58)(32-65)(33-61)(34-73)(35-82)(36-101)(37-66)(38-60)(39-103)(40-105)(41-62)(42-75)(43-71)(44-86)(45-85)(46-87)(47-84)(48-100)(49-72)(50-104)(51-91)(52-105)(53-123)(54-55)(54-93)(55-94)(56-58)(56-102)(57-59)(57-99)(58-93)(59-92)(60-82)(60-95)(61-72)(61-74)(62-63)(62-100)(63-96)(64-65)(64-101)(65-97)(66-97)(66-98)(67-70)(67-77)(68-70)(68-118)(69-77)(69-118)(71-73)(71-94)(72-75)(73-104)(74-110)(75-114)(76-79)(76-119)(78-79)(78-81)(80-81)(80-119)(82-103)(83-85)(83-86)(84-86)(84-87)(85-120)(87-120)(88-89)(88-117)(89-90)(90-91)(91-105)(92-108)(92-109)(93-106)(94-111)(95-107)(95-115)(96-98)(96-113)(97-112)(98-116)(99-124)(100-127)(101-126)(102-128)(103-121)(104-129)(105-123)(106-111)(106-128)(107-108)(107-121)(108-124)(109-115)(109-125)(110-114)(110-122)(111-129)(112-113)(112-126)(113-127)(114-125)(115-122)(116-123)(116-130)(117-131)(118-131)(119-131)(120-131)(124-132)(125-132)(126-132)(127-132)(128-132)(129-132)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 26 | — | 10.1021/jacs.1c01424 | 2021 |
| A549 | 32 | — | 10.1021/jacs.1c01424 | 2021 |
| HLF | 36 | — | 10.1021/jacs.1c01424 | 2021 |
| A549cisR | 38 | — | 10.1021/jacs.1c01424 | 2021 |
| MDA-MB-231 | 46 | — | 10.1021/jacs.1c01424 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«These results suggest that mitophagy and apoptosis are involved in Ru1-induced cell death.»
Autophagy
high
«Transmission electron microscopy shows that some of the mitochondria are enclosed in double-membrane structures after A549 cells are treated with Ru1 for 24 h, which indicates that mitochondria are de...»