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Complex #246 — Ru(2) [Ru1]

2D Structure

Structure
⬇ MOL V3000

Info

ID246
MetalRu
Oxidation state2
Charge4
Donor atoms{"N": 6}
AbbreviationRu1
SMILESO=C(NCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)c1cc2cccnc2c2ncccc12.O=C(NCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)c1cc2cccnc2c2ncccc12.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1

TUCAN

C92H80N10O2P2Ru/(1-86)(2-148)(3-84)(4-129)(5-165)(6-87)(7-81)(8-130)(9-130)(10-131)(11-131)(12-132)(13-132)(14-89)(15-82)(16-108)(17-123)(18-100)(19-98)(20-85)(21-146)(22-110)(23-88)(24-90)(25-129)(26-135)(27-93)(28-165)(29-92)(30-91)(31-104)(32-133)(33-134)(34-134)(35-151)(36-151)(37-103)(38-94)(39-147)(40-150)(41-96)(42-136)(43-166)(44-111)(45-83)(46-152)(47-152)(48-97)(49-99)(50-101)(51-121)(52-122)(53-120)(54-95)(55-124)(56-119)(57-112)(58-102)(59-135)(60-133)(61-166)(62-136)(63-105)(64-106)(65-107)(66-149)(67-113)(68-117)(69-145)(70-109)(71-118)(72-126)(73-114)(74-127)(75-128)(76-115)(77-116)(78-125)(79-175)(80-176)(81-126)(81-155)(82-84)(82-167)(83-86)(83-137)(84-85)(85-87)(86-147)(87-88)(88-167)(89-91)(89-93)(90-91)(90-94)(92-96)(92-103)(93-168)(94-168)(95-97)(95-103)(96-169)(97-169)(98-120)(98-146)(99-102)(99-170)(100-122)(100-145)(101-105)(101-170)(102-111)(104-107)(104-141)(105-111)(106-113)(106-171)(107-148)(108-138)(108-144)(109-117)(109-171)(110-124)(110-150)(112-113)(112-117)(114-115)(114-142)(115-149)(116-118)(116-172)(118-127)(119-140)(119-143)(120-138)(121-123)(121-126)(122-139)(123-157)(124-140)(125-128)(125-172)(127-128)(129-130)(129-165)(130-131)(131-132)(132-151)(133-134)(133-135)(134-152)(135-136)(136-166)(137-156)(137-161)(138-154)(139-153)(139-158)(140-162)(141-143)(141-159)(142-144)(142-160)(143-163)(144-164)(145-178)(146-179)(147-173)(148-180)(149-181)(150-182)(151-175)(152-176)(153-156)(153-178)(154-160)(154-179)(155-157)(155-174)(156-173)(157-177)(158-161)(158-177)(159-162)(159-180)(160-181)(161-174)(162-182)(163-175)(163-183)(164-176)(164-184)(165-185)(166-186)(167-185)(168-185)(169-185)(170-186)(171-186)(172-186)(177-187)(178-187)(179-187)(180-187)(181-187)(182-187)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HeLa3— 10.1021/jacs.1c01424 2021
A5494.4— 10.1021/jacs.1c01424 2021
A549cisR7.4— 10.1021/jacs.1c01424 2021
MDA-MB-23110— 10.1021/jacs.1c01424 2021
HLF54— 10.1021/jacs.1c01424 2021

🧬 Cell Death Types (2)

Apoptosis high
«These results suggest that mitophagy and apoptosis are involved in Ru1-induced cell death.»
Autophagy high
«Transmission electron microscopy shows that some of the mitochondria are enclosed in double-membrane structures after A549 cells are treated with Ru1 for 24 h, which indicates that mitochondria are de...»