Info
| ID | 2446 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 1} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(Nc1cc2cccnc2c2ncccc12)OCCCCCCSc1ccc([N+](=O)[O-])c2nonc12.[Cl-] |
TUCAN
C35H36N6O5RuS/(1-37)(2-37)(3-37)(4-53)(5-41)(6-51)(7-52)(8-61)(9-60)(10-52)(11-70)(12-40)(13-68)(14-48)(15-68)(16-50)(17-54)(18-70)(19-53)(20-43)(21-51)(22-47)(23-54)(24-49)(25-38)(26-42)(27-59)(28-38)(29-44)(30-38)(31-39)(32-46)(33-45)(34-39)(35-39)(36-72)(37-56)(38-59)(39-59)(40-41)(40-60)(41-55)(42-44)(42-56)(43-58)(43-66)(44-57)(45-46)(45-57)(46-56)(47-48)(47-71)(48-64)(49-50)(49-58)(50-61)(51-54)(51-68)(52-53)(52-54)(53-70)(55-65)(55-66)(57-59)(58-67)(60-76)(61-77)(62-63)(62-64)(62-74)(63-71)(63-73)(64-75)(65-67)(65-76)(66-72)(67-77)(68-81)(69-72)(69-78)(69-81)(70-83)(71-83)(73-82)(74-82)(75-79)(75-80)(76-84)(77-84)(81-84)(82-84)(83-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 2.4 | — | 10.1021/acs.inorgchem.1c01482 | 2021 |
| MCF-7 | 8.4 | — | 10.1021/acs.inorgchem.1c01482 | 2021 |
| LO2 | 16 | — | 10.1021/acs.inorgchem.1c01482 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−3 produce high incidences of early to late apoptosis in A549 cells (80.5−93.6%) and complexes 1−3 probably induced cell apoptosis by mitochondrial apoptotic pathway.»