Info
| ID | 2445 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 1} |
| Abbreviation | 1 |
| SMILES | O=C(Nc1cc2cccnc2c2ncccc12)OCCCCCCSc1ccc([N+](=O)[O-])c2nonc12.[Cl-].c1ccccc1 |
TUCAN
C31H28N6O5RuS/(1-29)(2-58)(3-44)(4-36)(5-56)(6-45)(7-43)(8-43)(9-45)(10-56)(11-30)(12-58)(13-38)(14-48)(15-49)(16-39)(17-40)(18-31)(19-35)(20-37)(21-41)(22-42)(23-32)(24-33)(25-44)(26-34)(27-42)(28-60)(29-30)(29-31)(30-32)(31-33)(32-34)(33-34)(35-40)(35-54)(36-37)(36-47)(37-48)(38-39)(38-49)(39-46)(40-59)(41-47)(41-55)(42-43)(42-44)(43-58)(44-45)(45-56)(46-51)(46-55)(47-52)(48-64)(49-65)(50-53)(50-59)(50-61)(51-52)(51-65)(52-64)(53-54)(53-62)(54-63)(55-60)(56-69)(57-60)(57-66)(57-69)(58-71)(59-71)(61-70)(62-70)(63-67)(63-68)(64-72)(65-72)(69-72)(70-72)(71-72)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 2.8 | — | 10.1021/acs.inorgchem.1c01482 | 2021 |
| MCF-7 | 10 | — | 10.1021/acs.inorgchem.1c01482 | 2021 |
| LO2 | 20 | — | 10.1021/acs.inorgchem.1c01482 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−3 produce high incidences of early to late apoptosis in A549 cells (80.5−93.6%) and complexes 1−3 probably induced cell apoptosis by mitochondrial apoptotic pathway.»