Info
| ID | 2428 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"S": 1, "N": 3, "P": 2} |
| Abbreviation | 4 |
| SMILES | O=C(O)c1ccc([S-])nc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C44H40N3O2P2RuS/(1-43)(2-41)(3-45)(4-69)(5-78)(6-55)(7-57)(8-59)(9-78)(10-51)(11-44)(12-79)(13-69)(14-46)(15-47)(16-70)(17-72)(18-74)(19-53)(20-52)(21-54)(22-62)(23-70)(24-79)(25-58)(26-56)(27-61)(28-64)(29-63)(30-60)(31-65)(32-73)(33-42)(34-66)(35-67)(36-48)(37-68)(38-50)(39-49)(40-89)(41-43)(41-44)(42-51)(42-72)(43-45)(44-80)(45-46)(46-80)(47-55)(47-81)(48-51)(48-75)(49-50)(49-84)(50-71)(52-55)(52-57)(53-57)(53-81)(54-59)(54-82)(56-62)(56-82)(58-59)(58-62)(60-63)(60-65)(61-63)(61-83)(64-65)(64-83)(66-67)(66-74)(67-68)(68-76)(69-70)(69-78)(70-79)(71-73)(71-77)(72-86)(73-85)(74-87)(75-76)(75-86)(76-87)(77-88)(77-89)(78-90)(79-91)(80-90)(81-90)(82-91)(83-91)(84-85)(84-92)(85-93)(86-93)(87-93)(89-93)(90-93)(91-93)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HL60 | 8.7 | — | 10.3389/fonc.2019.00562 | 2019 |
| MDA-MB-231 | 11 | — | 10.1039/C9DT01905G | 2019 |
| MCF-7 | 11 | — | 10.1039/C9DT01905G | 2019 |
| A549 | 12 | — | 10.1039/C9DT01905G | 2019 |
| MRC-5 | 12 | — | 10.1039/C9DT01905G | 2019 |
| K-562 | 13 | — | 10.3389/fonc.2019.00562 | 2019 |
| HepG2 | 14 | — | 10.3389/fonc.2019.00562 | 2019 |
| DU-145 | 16 | — | 10.1039/C9DT01905G | 2019 |
| B16-F10 | 18 | — | 10.3389/fonc.2019.00562 | 2019 |
| HepG2 | 23 | — | 10.1039/C9DT01905G | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«coincubation with a pan-caspase inhibitor (Z-VAD(OMe)-FMK) reduced the levels of apoptosis that were induced by these compounds compared to those in the negative controls, indicating that cell death t...»