Info
| ID | 2427 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "S": 1, "P": 1} |
| Abbreviation | 3 |
| SMILES | Nc1cc(N)nc([S-])n1.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C42H41N6P2RuS/(1-45)(2-46)(3-77)(4-43)(5-42)(6-57)(7-44)(8-51)(9-77)(10-69)(11-69)(12-47)(13-52)(14-70)(15-50)(16-71)(17-78)(18-56)(19-53)(20-61)(21-70)(22-78)(23-58)(24-54)(25-55)(26-59)(27-60)(28-63)(29-64)(30-62)(31-65)(32-48)(33-49)(34-67)(35-66)(36-72)(37-68)(38-84)(39-84)(40-85)(41-85)(42-43)(42-44)(43-45)(44-46)(45-79)(46-79)(47-51)(47-80)(48-49)(48-50)(49-73)(50-71)(51-57)(52-53)(52-57)(53-80)(54-56)(54-81)(55-58)(55-81)(56-61)(58-61)(59-60)(59-64)(60-82)(62-63)(62-82)(63-64)(65-66)(65-72)(66-67)(67-74)(68-75)(68-76)(69-70)(69-77)(70-78)(71-88)(72-89)(73-74)(73-88)(74-89)(75-84)(75-86)(76-85)(76-87)(77-90)(78-91)(79-90)(80-90)(81-91)(82-91)(83-86)(83-87)(83-92)(86-93)(87-93)(88-93)(89-93)(90-93)(91-93)
Measurements (14)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 2 | — | 10.1039/C9DT01905G | 2019 |
| B16-F10 | 3.9 | — | 10.3389/fonc.2019.00562 | 2019 |
| MCF-7 | 3.9 | — | 10.1039/C9DT01905G | 2019 |
| A549 | 4.2 | — | 10.1039/C9DT01905G | 2019 |
| K-562 | 4.6 | — | 10.3389/fonc.2019.00562 | 2019 |
| SCC-4 | 4.7 | — | 10.3389/fonc.2019.00562 | 2019 |
| HL60 | 5 | — | 10.3389/fonc.2019.00562 | 2019 |
| HSC-3 | 5.2 | — | 10.3389/fonc.2019.00562 | 2019 |
| DU-145 | 5.8 | — | 10.1039/C9DT01905G | 2019 |
| HCT-116 | 5.9 | — | 10.3389/fonc.2019.00562 | 2019 |
| HepG2 | 6.8 | — | 10.1039/C9DT01905G | 2019 |
| HepG2 | 7.2 | — | 10.3389/fonc.2019.00562 | 2019 |
| MRC-5 | 8.3 | — | 10.1039/C9DT01905G | 2019 |
| MCF-7 | 8.7 | — | 10.3389/fonc.2019.00562 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«coincubation with a pan-caspase inhibitor (Z-VAD(OMe)-FMK) reduced the levels of apoptosis that were induced by these compounds compared to those in the negative controls, indicating that cell death t...»