Info
| ID | 2426 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "S": 1, "P": 2} |
| Abbreviation | 2 |
| SMILES | Cn1ccnc1[S-].c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C42H41N4P2RuS/(1-68)(2-49)(3-68)(4-52)(5-43)(6-55)(7-44)(8-72)(9-73)(10-42)(11-45)(12-77)(13-46)(14-47)(15-77)(16-78)(17-53)(18-57)(19-58)(20-69)(21-69)(22-54)(23-59)(24-56)(25-48)(26-61)(27-62)(28-63)(29-60)(30-78)(31-64)(32-65)(33-66)(34-50)(35-51)(36-70)(37-70)(38-70)(39-71)(40-74)(41-67)(42-43)(42-44)(43-49)(44-52)(45-47)(45-55)(46-47)(46-57)(48-53)(48-54)(49-79)(50-64)(50-75)(51-66)(51-76)(52-79)(53-58)(54-59)(55-80)(56-61)(56-62)(57-80)(58-81)(59-81)(60-62)(60-63)(61-82)(63-82)(64-65)(65-72)(66-67)(67-73)(68-69)(68-77)(69-78)(70-84)(71-74)(71-85)(72-86)(73-87)(74-84)(75-76)(75-86)(76-87)(77-88)(78-89)(79-88)(80-88)(81-89)(82-89)(83-84)(83-85)(83-90)(85-91)(86-91)(87-91)(88-91)(89-91)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.11 | — | 10.1039/C9DT01905G | 2019 |
| A549 | 0.22 | — | 10.1039/C9DT01905G | 2019 |
| MRC-5 | 1.2 | — | 10.1039/C9DT01905G | 2019 |
| K-562 | 1.4 | — | 10.3389/fonc.2019.00562 | 2019 |
| B16-F10 | 1.8 | — | 10.3389/fonc.2019.00562 | 2019 |
| HL60 | 2 | — | 10.3389/fonc.2019.00562 | 2019 |
| DU-145 | 2 | — | 10.1039/C9DT01905G | 2019 |
| HepG2 | 2.6 | — | 10.3389/fonc.2019.00562 | 2019 |
| MCF-7 | 4.2 | — | 10.1039/C9DT01905G | 2019 |
| HepG2 | 6.2 | — | 10.1039/C9DT01905G | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«coincubation with a pan-caspase inhibitor (Z-VAD(OMe)-FMK) reduced the levels of apoptosis that were induced by these compounds compared to those in the negative controls, indicating that cell death t...»