Info
| ID | 2419 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1} |
| Abbreviation | 1 |
| SMILES | COc1ccc(C(=O)/C=C(\[O-])c2ccc(C(C)(C)C)cc2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C30ClO3Ru/(1-26)(2-23)(3-20)(4-26)(5-20)(6-26)(7-8)(7-23)(8-22)(9-19)(9-22)(10-12)(10-28)(11-15)(11-24)(12-25)(13-14)(13-25)(14-28)(15-21)(16-29)(16-30)(17-18)(17-24)(18-21)(19-23)(20-22)(21-26)(24-29)(25-30)(27-33)(28-33)(29-31)(30-32)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NIH-3T3 | 3 | — | 10.1016/j.jinorgbio.2018.08.00... | 2018 |
| HeLa | 3 | — | 10.1016/j.jinorgbio.2018.08.00... | 2018 |
| A549 | 4 | — | 10.1016/j.jinorgbio.2018.08.00... | 2018 |
| MCF-7 | 4 | — | 10.1016/j.jinorgbio.2018.08.00... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«These results confirmed that both complexes induced cytotoxicity followed by apoptosis in the cancer cell lines through subG1 phase arrest. ... From the apoptosis assays, it was clear that 5 μM of com...»
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Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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