Info
| ID | 2414 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 2} |
| Abbreviation | complex 4 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(COc1ccc2ccc(=O)oc2c1)OCc1ccncc1.O=C([O-])CC(=O)[O-] |
TUCAN
C30H29NO9Ru/(1-53)(2-30)(3-30)(4-38)(5-30)(6-50)(7-34)(8-44)(9-43)(10-53)(11-51)(12-44)(13-52)(14-36)(15-35)(16-41)(17-33)(18-31)(19-37)(20-39)(21-31)(22-31)(23-32)(24-40)(25-49)(26-42)(27-52)(28-32)(29-32)(30-46)(31-49)(32-49)(33-35)(33-55)(34-36)(34-56)(35-45)(36-45)(37-38)(37-46)(38-47)(39-40)(39-47)(40-46)(41-48)(41-50)(42-48)(42-51)(43-54)(43-55)(44-57)(44-59)(45-54)(47-49)(48-52)(50-60)(51-60)(52-67)(53-58)(53-69)(54-68)(55-69)(56-61)(56-68)(57-62)(57-63)(58-64)(58-67)(59-65)(59-66)(60-70)(68-70)(69-70)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 1.3e+02 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| HepG2 | 1.4e+02 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| A549 | 1.6e+02 | — | 10.1021/acs.organomet.7b00842 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometry studies showed that complexes 2−4 can block the cell cycle in G2/M phase and produce death of tumor cells through an apoptotic pathway. Moreover, complexes 2−4 can activate the expressi...»