Info
| ID | 2413 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 2} |
| Abbreviation | complex 3 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(COc1ccc2ccc(=O)oc2c1)OCc1ccncc1.O=C([O-])C(=O)[O-] |
TUCAN
C29H27NO9Ru/(1-28)(2-28)(3-29)(4-28)(5-49)(6-33)(7-35)(8-49)(9-34)(10-50)(11-50)(12-32)(13-29)(14-36)(15-37)(16-29)(17-30)(18-39)(19-30)(20-38)(21-30)(22-46)(23-40)(24-41)(25-31)(26-47)(27-48)(28-44)(29-46)(30-46)(31-34)(31-54)(32-42)(32-47)(33-35)(33-51)(34-43)(35-43)(36-37)(36-44)(37-45)(38-39)(38-45)(39-44)(40-51)(40-52)(41-42)(41-48)(42-49)(43-52)(45-46)(47-57)(48-57)(49-64)(50-56)(50-65)(51-65)(52-66)(53-55)(53-58)(53-60)(54-59)(54-66)(55-61)(55-63)(56-62)(56-64)(57-67)(65-67)(66-67)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 85 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| A549 | 87 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| HepG2 | 1.2e+02 | — | 10.1021/acs.organomet.7b00842 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometry studies showed that complexes 2−4 can block the cell cycle in G2/M phase and produce death of tumor cells through an apoptotic pathway. Moreover, complexes 2−4 can activate the expressi...»