Info
| ID | 2412 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | complex 2 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(COc1ccc2ccc(=O)oc2c1)OCc1ccncc1.[Cl-].[Cl-] |
TUCAN
C27Cl2NO5Ru/(1-16)(2-15)(3-15)(4-6)(4-17)(5-9)(5-24)(6-16)(7-19)(7-20)(8-24)(8-25)(9-18)(10-13)(10-16)(11-12)(11-27)(12-18)(13-17)(14-19)(14-21)(15-17)(18-25)(19-23)(20-28)(21-28)(22-26)(22-31)(23-32)(24-31)(25-33)(26-30)(26-32)(27-29)(27-33)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 66 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| A549 | 72 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| HepG2 | 79 | — | 10.1021/acs.organomet.7b00842 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometry studies showed that complexes 2−4 can block the cell cycle in G2/M phase and produce death of tumor cells through an apoptotic pathway. Moreover, complexes 2−4 can activate the expressi...»