Info
| ID | 2390 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5 |
| SMILES | CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C28H38N2Ru/(1-40)(2-49)(3-40)(4-48)(5-40)(6-44)(7-50)(8-44)(9-51)(10-63)(11-52)(12-44)(13-54)(14-39)(15-41)(16-41)(17-41)(18-42)(19-42)(20-42)(21-43)(22-43)(23-43)(24-45)(25-53)(26-45)(27-45)(28-46)(29-39)(30-39)(31-60)(32-46)(33-46)(34-47)(35-64)(36-47)(37-55)(38-47)(39-56)(40-60)(41-61)(42-61)(43-61)(44-60)(45-62)(46-62)(47-62)(48-49)(48-56)(49-58)(50-54)(50-56)(51-57)(51-65)(52-57)(52-63)(53-59)(53-66)(54-58)(55-59)(55-64)(57-61)(58-60)(59-62)(63-67)(64-68)(65-66)(65-67)(66-68)(67-69)(68-69)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 4.3 | — | 10.1016/j.jinorgbio.2015.07.01... | 2015 |
| MDA-MB-231 | 6.8 | — | 10.1016/j.jinorgbio.2015.07.01... | 2015 |
| T24 | 12 | — | 10.3390/ijms241511896 | 2023 |
| A549 | 18 | — | 10.1016/j.jinorgbio.2015.07.01... | 2015 |
| HepG2 | 30 | — | 10.3390/ijms241511896 | 2023 |
| MCF-10A | 48 | — | 10.3390/ijms241511896 | 2023 |
| L-929 | 90 | — | 10.1016/j.jinorgbio.2015.07.01... | 2015 |
| Vero | — | — | 10.3390/ijms241511896 | 2023 |
| EA.hy926 | — | — | 10.3390/ijms241511896 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence imaging and flow cytometry analysis demonstrate that 1 and 2 effectively penetrate the membrane and promote T24 cell death through the apoptotic pathway, mainly inducing early apoptosis o...»
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