Info
| ID | 2384 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 1-(PF₆)₂ |
| SMILES | CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.Nc1nc(Nc2ccccc2)nc(-c2ccccn2)n1 |
TUCAN
C50H60N10Ru/(1-61)(2-61)(3-61)(4-62)(5-79)(6-98)(7-62)(8-62)(9-63)(10-63)(11-87)(12-75)(13-63)(14-64)(15-64)(16-64)(17-76)(18-99)(19-80)(20-65)(21-65)(22-83)(23-65)(24-66)(25-66)(26-66)(27-67)(28-67)(29-67)(30-68)(31-68)(32-68)(33-74)(34-69)(35-69)(36-73)(37-82)(38-100)(39-85)(40-97)(41-88)(42-69)(43-101)(44-70)(45-86)(46-70)(47-78)(48-70)(49-84)(50-71)(51-77)(52-81)(53-71)(54-71)(55-72)(56-72)(57-72)(58-114)(59-111)(60-111)(61-93)(62-93)(63-93)(64-94)(65-94)(66-94)(67-95)(68-95)(69-95)(70-96)(71-96)(72-96)(73-74)(73-88)(74-102)(75-89)(75-103)(76-90)(76-104)(77-81)(77-102)(78-79)(78-97)(79-87)(80-89)(80-98)(81-88)(82-90)(82-99)(83-91)(83-105)(84-92)(84-107)(85-91)(85-100)(86-92)(86-101)(87-106)(89-93)(90-94)(91-95)(92-96)(97-112)(98-117)(99-118)(100-119)(101-120)(102-114)(103-104)(103-117)(104-118)(105-107)(105-119)(106-108)(106-112)(107-120)(108-113)(108-116)(109-114)(109-115)(109-116)(110-111)(110-113)(110-115)(115-121)(116-121)(117-121)(118-121)(119-121)(120-121)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 30 | — | 10.1021/ic061518s | 2007 |
| KB-3-1 | 52 | — | 10.1021/ic061518s | 2007 |
| HeLa | 60 | — | 10.1021/ic061518s | 2007 |
| CCD-19Lu | 1.5e+02 | — | 10.1021/ic061518s | 2007 |
| KB-V1 | 2e+02 | — | 10.1021/ic061518s | 2007 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to confocal microscopic and flow cytometric studies, 1·(PF6)2 and 2 induced apoptosis (50−60%) in cancer cells with <5% necrosis detected.»
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