Info
| ID | 236 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru2 |
| SMILES | c1c[nH]c(-c2ncc[nH]2)n1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C26H22N8Ru/(1-35)(2-28)(3-36)(4-37)(5-27)(6-40)(7-38)(8-31)(9-29)(10-32)(11-30)(12-34)(13-33)(14-39)(15-42)(16-23)(17-24)(18-25)(19-26)(20-41)(21-49)(22-50)(23-28)(23-43)(24-31)(24-44)(25-32)(25-45)(26-34)(26-46)(27-28)(27-35)(29-31)(29-36)(30-32)(30-37)(33-34)(33-40)(35-51)(36-52)(37-53)(38-39)(38-55)(39-49)(40-54)(41-42)(41-50)(42-56)(43-44)(43-51)(44-52)(45-46)(45-53)(46-54)(47-48)(47-49)(47-55)(48-50)(48-56)(51-57)(52-57)(53-57)(54-57)(55-57)(56-57)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 89 | — | 10.1039/c3nj00542a | 2013 |
| HepG2 | 1e+02 | — | 10.1039/c3nj00542a | 2013 |
| A549 | 1.3e+02 | — | 10.1039/c3nj00542a | 2013 |
| A549 | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
| HepG2 | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
| HLF | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
| LO2 | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis and evaluation of mitochondrial membrane potential demonstrated that complex 2 inhibited the growth of HeLa cells through induction of apoptotic cell death.»