Info
| ID | 235 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru1 |
| SMILES | c1c[nH]cn1.c1c[nH]cn1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C26H24N8Ru/(1-37)(2-26)(3-38)(4-39)(5-28)(6-41)(7-33)(8-31)(9-34)(10-32)(11-36)(12-35)(13-40)(14-49)(15-25)(16-27)(17-29)(18-30)(19-43)(20-50)(21-44)(22-42)(23-51)(24-52)(25-26)(25-45)(26-28)(27-33)(27-46)(28-37)(29-34)(29-47)(30-36)(30-48)(31-33)(31-38)(32-34)(32-39)(35-36)(35-41)(37-54)(38-55)(39-56)(40-43)(40-51)(41-57)(42-44)(42-52)(43-53)(44-58)(45-46)(45-54)(46-55)(47-48)(47-56)(48-57)(49-51)(49-53)(50-52)(50-58)(53-59)(54-59)(55-59)(56-59)(57-59)(58-59)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 p53-/- | 0.53 | — | 10.1021/jm5005946 | 2014 |
| HCT-116 p53+/+ | 1 | — | 10.1021/jm5005946 | 2014 |
| A2780 | 8.2 | — | 10.1021/jm5005946 | 2014 |
| A549 | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
| HepG2 | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
| HLF | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
| LO2 | — | — | 10.1016/j.jinorgbio.2022.11180... | 2022 |
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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