Info
| ID | 2300 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2 |
| SMILES | Oc1c(Br)cc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1Br.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C43H26Br2N8ORu/(1-31)(2-52)(3-27)(4-28)(5-41)(6-35)(7-53)(8-55)(9-32)(10-33)(11-29)(12-36)(13-44)(14-38)(15-37)(16-39)(17-42)(18-30)(19-56)(20-54)(21-43)(22-57)(23-34)(24-40)(25-71)(26-78)(27-31)(27-52)(28-29)(28-45)(29-47)(30-34)(30-48)(31-45)(32-35)(32-53)(33-39)(33-55)(34-49)(35-47)(36-37)(36-51)(37-54)(38-44)(38-46)(39-48)(40-42)(40-56)(41-50)(41-68)(42-49)(43-50)(43-69)(44-57)(45-58)(46-61)(46-63)(47-59)(48-62)(49-64)(50-66)(51-60)(51-65)(52-72)(53-73)(54-70)(55-76)(56-77)(57-75)(58-59)(58-72)(59-73)(60-63)(60-70)(61-65)(61-74)(62-64)(62-76)(63-75)(64-77)(65-71)(66-71)(66-74)(67-68)(67-69)(67-78)(68-79)(69-80)(72-81)(73-81)(74-81)(75-81)(76-81)(77-81)(78-81)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | 22 | — | 10.1016/j.ejmech.2010.03.042 | 2010 |
| MCF-7 | 22 | — | 10.1016/j.ejmech.2010.03.042 | 2010 |
| HepG2 | 28 | — | 10.1016/j.ejmech.2010.03.042 | 2010 |
| C6 | 31 | — | 10.1016/j.ejmech.2010.03.042 | 2010 |
| BEL-7402 | 33 | — | 10.1016/j.ejmech.2010.03.042 | 2010 |
🧬 Cell Death Types (1)
Apoptosis
high
«Cytotoxicity evaluation in vitro shows that the ligand and its complex 2 all displayed antitumor activity against the selected tumor cell lines and complexes 1 and 2 can induce the apoptosis of BEL-74...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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