Info
| ID | 230 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 3 |
| SMILES | c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C43H28N8Ru/(1-60)(2-49)(3-31)(4-58)(5-30)(6-33)(7-41)(8-59)(9-29)(10-61)(11-57)(12-42)(13-43)(14-32)(15-38)(16-37)(17-44)(18-46)(19-48)(20-39)(21-34)(22-62)(23-47)(24-45)(25-35)(26-40)(27-36)(28-73)(29-35)(29-50)(30-31)(30-50)(31-58)(32-34)(32-51)(33-41)(33-51)(34-52)(35-54)(36-38)(36-40)(37-38)(37-55)(39-40)(39-55)(41-59)(42-48)(42-60)(43-44)(43-61)(44-52)(45-46)(45-62)(46-54)(47-49)(47-53)(48-56)(49-57)(50-63)(51-64)(52-67)(53-66)(53-69)(54-68)(55-71)(56-65)(56-70)(57-72)(58-74)(59-76)(60-75)(61-77)(62-79)(63-68)(63-74)(64-67)(64-76)(65-66)(65-75)(66-72)(67-77)(68-79)(69-70)(69-73)(70-78)(71-73)(71-78)(74-80)(75-80)(76-80)(77-80)(78-80)(79-80)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 29 | — | 10.1021/acs.jmedchem.3c00322 | 2023 |
| HeLa | 49 | — | 10.1039/c7ra00658f | 2017 |
| CaSki | 53 | — | 10.1039/c7ra00658f | 2017 |
| HeLa | — | — | 10.1038/srep19449 | 2016 |
| A549 | — | — | 10.1038/srep19449 | 2016 |
| A549cisR | — | — | 10.1038/srep19449 | 2016 |
| LO2 | — | — | 10.1038/srep19449 | 2016 |
| A549R MCTSs | — | — | 10.1038/srep19449 | 2016 |
| SiHa | — | — | 10.1039/c7ra00658f | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«A double-staining Annexin V/PI apoptosis kit and flow cytometry were used to investigate the nature of A549R cell death induced by complex 4. The results are shown in Fig. 7b. At a concentration as lo...»