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Complex #230 — Ru(2) [3]

2D Structure

Structure
⬇ MOL V3000

Info

ID230
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 8}
Abbreviation3
SMILESc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12

TUCAN

C43H28N8Ru/(1-60)(2-49)(3-31)(4-58)(5-30)(6-33)(7-41)(8-59)(9-29)(10-61)(11-57)(12-42)(13-43)(14-32)(15-38)(16-37)(17-44)(18-46)(19-48)(20-39)(21-34)(22-62)(23-47)(24-45)(25-35)(26-40)(27-36)(28-73)(29-35)(29-50)(30-31)(30-50)(31-58)(32-34)(32-51)(33-41)(33-51)(34-52)(35-54)(36-38)(36-40)(37-38)(37-55)(39-40)(39-55)(41-59)(42-48)(42-60)(43-44)(43-61)(44-52)(45-46)(45-62)(46-54)(47-49)(47-53)(48-56)(49-57)(50-63)(51-64)(52-67)(53-66)(53-69)(54-68)(55-71)(56-65)(56-70)(57-72)(58-74)(59-76)(60-75)(61-77)(62-79)(63-68)(63-74)(64-67)(64-76)(65-66)(65-75)(66-72)(67-77)(68-79)(69-70)(69-73)(70-78)(71-73)(71-78)(74-80)(75-80)(76-80)(77-80)(78-80)(79-80)

Measurements (9)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MDA-MB-23129— 10.1021/acs.jmedchem.3c00322 2023
HeLa49— 10.1039/c7ra00658f 2017
CaSki53— 10.1039/c7ra00658f 2017
HeLa—— 10.1038/srep19449 2016
A549—— 10.1038/srep19449 2016
A549cisR—— 10.1038/srep19449 2016
LO2—— 10.1038/srep19449 2016
A549R MCTSs—— 10.1038/srep19449 2016
SiHa—— 10.1039/c7ra00658f 2017

🧬 Cell Death Types (1)

Apoptosis high
«A double-staining Annexin V/PI apoptosis kit and flow cytometry were used to investigate the nature of A549R cell death induced by complex 4. The results are shown in Fig. 7b. At a concentration as lo...»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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