Info
| ID | 2238 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Complex 1 |
| SMILES | c1ccc(-c2ccc3ccc4ccc(-c5ccccc5)nc4c3n2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C44H32N6Ru/(1-48)(2-45)(3-65)(4-35)(5-33)(6-66)(7-46)(8-53)(9-44)(10-67)(11-34)(12-38)(13-68)(14-43)(15-47)(16-37)(17-39)(18-50)(19-40)(20-41)(21-57)(22-49)(23-59)(24-54)(25-56)(26-36)(27-42)(28-60)(29-52)(30-55)(31-58)(32-51)(33-35)(33-65)(34-38)(34-66)(35-36)(36-69)(37-39)(37-67)(38-42)(39-52)(40-41)(40-55)(41-68)(42-70)(43-45)(43-46)(44-48)(44-71)(45-47)(46-61)(47-50)(48-63)(49-57)(49-60)(50-61)(51-59)(51-73)(52-74)(53-54)(53-63)(54-64)(55-76)(56-57)(56-62)(58-60)(58-62)(59-64)(61-71)(62-73)(63-72)(64-75)(65-78)(66-79)(67-81)(68-82)(69-76)(69-78)(70-74)(70-79)(71-77)(72-75)(72-77)(73-80)(74-81)(75-80)(76-82)(77-83)(78-83)(79-83)(80-83)(81-83)(82-83)
Measurements (11)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16 | 55 | 0.82 | 10.1002/ejic.201800194 | 2018 |
| A549 | — | 6.2 | 10.3390/ph17010050 | 2024 |
| A549 | — | 4 | 10.3390/ph17010050 | 2024 |
| A549 | — | 2.6 | 10.3390/ph17010050 | 2024 |
| MDA-MB-231 | — | 8.3 | 10.1016/j.cbi.2020.109317 | 2021 |
| MDA-MB-231 | — | 4 | 10.1016/j.cbi.2020.109317 | 2021 |
| MDA-MB-231 | — | 1 | 10.1016/j.cbi.2020.109317 | 2021 |
| A549 | — | 2.5 | 10.1002/ejic.201800194 | 2018 |
| Caco-2 | — | 1.5 | 10.1002/ejic.201800194 | 2018 |
| HT-29 | — | 2 | 10.1002/ejic.201800194 | 2018 |
| MDA-MB-231 | — | 1 | 10.1002/ejic.201800194 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«it was observed that treatment with etoposide and complex 1 after light activation led to a significant increase in apoptosis (34.4 ± 1.7% and 62.5 ± 1.3% early apoptotic cells, respectively)»