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Complex #2237 — Ru(2) [2]

2D Structure

Structure
⬇ MOL V3000

Info

ID2237
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 4, "S": 1, "P": 2}
Abbreviation2
SMILESCc1cc(=O)nc([S-])[nH]1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C51H43N4OP2RuS/(1-45)(2-47)(3-46)(4-48)(5-51)(6-67)(7-52)(8-55)(9-53)(10-58)(11-54)(12-59)(13-44)(14-72)(15-44)(16-50)(17-56)(18-57)(19-63)(20-60)(21-61)(22-69)(23-65)(24-62)(25-66)(26-70)(27-73)(28-74)(29-77)(30-75)(31-78)(32-64)(33-71)(34-76)(35-82)(36-80)(37-81)(38-68)(39-49)(40-44)(41-79)(42-83)(43-95)(44-84)(45-47)(45-51)(46-47)(46-52)(48-50)(48-53)(49-84)(49-87)(50-55)(51-88)(52-88)(53-89)(54-55)(54-89)(56-58)(56-59)(57-58)(57-90)(59-60)(60-90)(61-63)(61-91)(62-63)(62-65)(64-66)(64-70)(65-69)(66-73)(67-68)(67-72)(68-85)(69-91)(70-74)(71-77)(71-78)(72-82)(73-92)(74-92)(75-77)(75-93)(76-78)(76-93)(79-81)(79-86)(80-81)(80-83)(82-96)(83-97)(84-95)(85-86)(85-96)(86-97)(87-98)(87-99)(88-100)(89-100)(90-100)(91-101)(92-101)(93-101)(94-95)(94-98)(94-102)(96-103)(97-103)(98-103)(100-103)(101-103)

Measurements (31)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
OVCAR-31.6— 10.1038/s41420-024-02036-w 2024
HL601.6— 10.1021/acsomega.9b01921 2020
A3752— 10.1038/s41420-024-02036-w 2024
K-5622.1— 10.1021/acsomega.9b01921 2020
SCC-92.5— 10.1038/s41420-024-02036-w 2024
B16-F102.8— 10.1038/s41420-024-02036-w 2024
MDA-MB-2313— 10.1038/s41420-024-02036-w 2024
B16-F103.1— 10.1021/acsomega.9b01921 2020
HepG23.2— 10.1038/s41420-024-02036-w 2024
SCC-43.5— 10.1038/s41420-024-02036-w 2024
SCC-253.6— 10.1038/s41420-024-02036-w 2024
U-87 MG3.7— 10.1038/s41420-024-02036-w 2024
DU-1453.7— 10.1038/s41420-024-02036-w 2024
KG-1a3.8— 10.1038/s41420-024-02036-w 2024
PBMC3.9— 10.1021/acsomega.9b01921 2020
PANC-14.1— 10.1038/s41420-024-02036-w 2024
HL604.1— 10.1038/s41420-024-02036-w 2024
CAL-274.3— 10.1038/s41420-024-02036-w 2024
HCT-1164.5— 10.1038/s41420-024-02036-w 2024
4T14.5— 10.1038/s41420-024-02036-w 2024
Jurkat4.9— 10.1038/s41420-024-02036-w 2024
NB45.2— 10.1038/s41420-024-02036-w 2024
HSC-35.5— 10.1038/s41420-024-02036-w 2024
THP-16.5— 10.1038/s41420-024-02036-w 2024
MCF-77.3— 10.1038/s41420-024-02036-w 2024
K-5627.7— 10.1038/s41420-024-02036-w 2024
BJ7.8— 10.1038/s41420-024-02036-w 2024
HepG29.1— 10.1021/acsomega.9b01921 2020
A54910— 10.1038/s41420-024-02036-w 2024
PBMC12— 10.1038/s41420-024-02036-w 2024
MRC-515— 10.1038/s41420-024-02036-w 2024

🧬 Cell Death Types (1)

Apoptosis high
«Both complexes induced a significant increase in the percentage of apoptotic cells in a time- and concentration-dependent manner, and no significant increase in the percentage of necrotic cells was de...»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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