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D-MPNN
Complex #2237 — Ru(2)
[2]
2D Structure
⬇ MOL V3000
Info
ID
2237
Metal
Ru
Oxidation state
2
Charge
1
Donor atoms
{"N": 4, "S": 1, "P": 2}
Abbreviation
2
SMILES
Cc1cc(=O)nc([S-])[nH]1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1
TUCAN
C51H43N4OP2RuS/(1-45)(2-47)(3-46)(4-48)(5-51)(6-67)(7-52)(8-55)(9-53)(10-58)(11-54)(12-59)(13-44)(14-72)(15-44)(16-50)(17-56)(18-57)(19-63)(20-60)(21-61)(22-69)(23-65)(24-62)(25-66)(26-70)(27-73)(28-74)(29-77)(30-75)(31-78)(32-64)(33-71)(34-76)(35-82)(36-80)(37-81)(38-68)(39-49)(40-44)(41-79)(42-83)(43-95)(44-84)(45-47)(45-51)(46-47)(46-52)(48-50)(48-53)(49-84)(49-87)(50-55)(51-88)(52-88)(53-89)(54-55)(54-89)(56-58)(56-59)(57-58)(57-90)(59-60)(60-90)(61-63)(61-91)(62-63)(62-65)(64-66)(64-70)(65-69)(66-73)(67-68)(67-72)(68-85)(69-91)(70-74)(71-77)(71-78)(72-82)(73-92)(74-92)(75-77)(75-93)(76-78)(76-93)(79-81)(79-86)(80-81)(80-83)(82-96)(83-97)(84-95)(85-86)(85-96)(86-97)(87-98)(87-99)(88-100)(89-100)(90-100)(91-101)(92-101)(93-101)(94-95)(94-98)(94-102)(96-103)(97-103)(98-103)(100-103)(101-103)
Measurements (31)
Cell line
IC₅₀ dark (µM)
IC₅₀ light (µM)
DOI
Year
OVCAR-3
1.6
—
10.1038/s41420-024-02036-w
2024
HL60
1.6
—
10.1021/acsomega.9b01921
2020
A375
2
—
10.1038/s41420-024-02036-w
2024
K-562
2.1
—
10.1021/acsomega.9b01921
2020
SCC-9
2.5
—
10.1038/s41420-024-02036-w
2024
B16-F10
2.8
—
10.1038/s41420-024-02036-w
2024
MDA-MB-231
3
—
10.1038/s41420-024-02036-w
2024
B16-F10
3.1
—
10.1021/acsomega.9b01921
2020
HepG2
3.2
—
10.1038/s41420-024-02036-w
2024
SCC-4
3.5
—
10.1038/s41420-024-02036-w
2024
SCC-25
3.6
—
10.1038/s41420-024-02036-w
2024
U-87 MG
3.7
—
10.1038/s41420-024-02036-w
2024
DU-145
3.7
—
10.1038/s41420-024-02036-w
2024
KG-1a
3.8
—
10.1038/s41420-024-02036-w
2024
PBMC
3.9
—
10.1021/acsomega.9b01921
2020
PANC-1
4.1
—
10.1038/s41420-024-02036-w
2024
HL60
4.1
—
10.1038/s41420-024-02036-w
2024
CAL-27
4.3
—
10.1038/s41420-024-02036-w
2024
HCT-116
4.5
—
10.1038/s41420-024-02036-w
2024
4T1
4.5
—
10.1038/s41420-024-02036-w
2024
Jurkat
4.9
—
10.1038/s41420-024-02036-w
2024
NB4
5.2
—
10.1038/s41420-024-02036-w
2024
HSC-3
5.5
—
10.1038/s41420-024-02036-w
2024
THP-1
6.5
—
10.1038/s41420-024-02036-w
2024
MCF-7
7.3
—
10.1038/s41420-024-02036-w
2024
K-562
7.7
—
10.1038/s41420-024-02036-w
2024
BJ
7.8
—
10.1038/s41420-024-02036-w
2024
HepG2
9.1
—
10.1021/acsomega.9b01921
2020
A549
10
—
10.1038/s41420-024-02036-w
2024
PBMC
12
—
10.1038/s41420-024-02036-w
2024
MRC-5
15
—
10.1038/s41420-024-02036-w
2024
🧬 Cell Death Types (1)
Apoptosis
high
«Both complexes induced a significant increase in the percentage of apoptotic cells in a time- and concentration-dependent manner, and no significant increase in the percentage of necrotic cells was de...»