Info
| ID | 2234 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 1, "P": 2} |
| Abbreviation | Complex 3 |
| SMILES | CC(C)CC(N)C(=O)[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C44H48N3O2P2Ru/(1-77)(2-77)(3-51)(4-57)(5-52)(6-63)(7-53)(8-58)(9-76)(10-54)(11-65)(12-87)(13-61)(14-55)(15-87)(16-49)(17-49)(18-81)(19-82)(20-88)(21-66)(22-62)(23-67)(24-79)(25-79)(26-69)(27-71)(28-56)(29-70)(30-64)(31-68)(32-72)(33-73)(34-88)(35-49)(36-60)(37-59)(38-75)(39-74)(40-50)(41-50)(42-50)(43-80)(44-78)(45-78)(46-85)(47-93)(48-93)(49-80)(50-80)(51-52)(51-53)(52-57)(53-63)(54-55)(54-65)(55-61)(56-62)(56-64)(57-89)(58-60)(58-81)(59-60)(59-83)(61-66)(62-67)(63-89)(64-69)(65-90)(66-90)(67-91)(68-70)(68-71)(69-91)(70-73)(71-92)(72-73)(72-92)(74-75)(74-76)(75-84)(76-82)(77-79)(77-87)(78-80)(78-85)(79-88)(81-94)(82-95)(83-84)(83-94)(84-95)(85-86)(85-93)(86-96)(86-97)(87-98)(88-99)(89-98)(90-98)(91-99)(92-99)(94-100)(95-100)(98-100)(99-100)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| K-562 | 36 | — | 10.1007/s12011-019-01976-0 | 2019 |
| S180 | 38 | — | 10.1371/journal.pone.0105865 | 2014 |
| L-929 | 47 | — | 10.1007/s12011-019-01976-0 | 2019 |
| L-929 | 47 | — | 10.1371/journal.pone.0105865 | 2014 |
| A549 | 53 | — | 10.1007/s12011-019-01976-0 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis revealed that the [Ru(gly)(bipy)(dppb)]PF6 complex (2) inhibited the growth of the tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive...»