Info
| ID | 2233 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 1, "P": 2} |
| Abbreviation | Complex 2 |
| SMILES | NCC(=O)[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C40H40N3O2P2Ru/(1-42)(2-43)(3-41)(4-44)(5-49)(6-45)(7-51)(8-75)(9-52)(10-55)(11-75)(12-67)(13-50)(14-53)(15-57)(16-67)(17-68)(18-58)(19-61)(20-60)(21-62)(22-54)(23-56)(24-63)(25-59)(26-76)(27-76)(28-68)(29-46)(30-69)(31-70)(32-47)(33-64)(34-71)(35-71)(36-48)(37-66)(38-65)(39-81)(40-81)(41-42)(41-45)(42-77)(43-49)(43-77)(44-51)(44-78)(45-49)(46-47)(46-48)(47-69)(48-72)(50-52)(50-78)(51-55)(52-55)(53-57)(53-60)(54-58)(54-60)(56-61)(56-63)(57-79)(58-79)(59-62)(59-63)(61-80)(62-80)(64-66)(64-70)(65-66)(65-73)(67-68)(67-75)(68-76)(69-82)(70-83)(71-74)(71-81)(72-73)(72-82)(73-83)(74-84)(74-85)(75-86)(76-87)(77-86)(78-86)(79-87)(80-87)(82-88)(83-88)(86-88)(87-88)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| K-562 | 7.8 | — | 10.1007/s12011-019-01976-0 | 2019 |
| MDA-MB-231 | 14 | — | 10.1016/j.poly.2014.07.024 | 2014 |
| S180 | 31 | — | 10.1371/journal.pone.0105865 | 2014 |
| DU-145 | 33 | — | 10.1016/j.poly.2014.07.024 | 2014 |
| L-929 | 52 | — | 10.1371/journal.pone.0105865 | 2014 |
| L-929 | 52 | — | 10.1007/s12011-019-01976-0 | 2019 |
| A549 | 98 | — | 10.1007/s12011-019-01976-0 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis revealed that the [Ru(gly)(bipy)(dppb)]PF6 complex (2) inhibited the growth of the tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive...»