Info
| ID | 2232 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 1, "P": 2} |
| Abbreviation | Complex 1 |
| SMILES | CC(N)C(=O)[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C41H42N3O2P2Ru/(1-48)(2-45)(3-44)(4-46)(5-52)(6-54)(7-47)(8-78)(9-55)(10-58)(11-78)(12-43)(13-43)(14-70)(15-53)(16-56)(17-60)(18-70)(19-71)(20-61)(21-64)(22-63)(23-65)(24-57)(25-59)(26-66)(27-62)(28-79)(29-79)(30-71)(31-43)(32-49)(33-72)(34-73)(35-50)(36-67)(37-76)(38-51)(39-69)(40-68)(41-84)(42-84)(43-76)(44-45)(44-48)(45-80)(46-52)(46-80)(47-54)(47-81)(48-52)(49-50)(49-51)(50-72)(51-74)(53-55)(53-81)(54-58)(55-58)(56-60)(56-63)(57-61)(57-63)(59-64)(59-66)(60-82)(61-82)(62-65)(62-66)(64-83)(65-83)(67-69)(67-73)(68-69)(68-75)(70-71)(70-78)(71-79)(72-85)(73-86)(74-75)(74-85)(75-86)(76-77)(76-84)(77-87)(77-88)(78-89)(79-90)(80-89)(81-89)(82-90)(83-90)(85-91)(86-91)(89-91)(90-91)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| K-562 | 9.5 | — | 10.1007/s12011-019-01976-0 | 2019 |
| S180 | 50 | — | 10.1371/journal.pone.0105865 | 2014 |
| A549 | 83 | — | 10.1007/s12011-019-01976-0 | 2019 |
| L-929 | 98 | — | 10.1007/s12011-019-01976-0 | 2019 |
| L-929 | 98 | — | 10.1371/journal.pone.0105865 | 2014 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis revealed that the [Ru(gly)(bipy)(dppb)]PF6 complex (2) inhibited the growth of the tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive...»