Info
| ID | 2208 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 1, "P": 2} |
| Abbreviation | RuMet |
| SMILES | CSCCC(N)C(=O)[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C43H46N3O2P2RuS/(1-49)(2-48)(3-50)(4-73)(5-82)(6-47)(7-52)(8-51)(9-61)(10-68)(11-69)(12-82)(13-73)(14-74)(15-53)(16-55)(17-74)(18-75)(19-80)(20-75)(21-67)(22-72)(23-54)(24-59)(25-56)(26-62)(27-83)(28-83)(29-60)(30-57)(31-58)(32-63)(33-64)(34-66)(35-65)(36-89)(37-76)(38-77)(39-71)(40-70)(41-88)(42-88)(43-88)(44-89)(45-90)(46-90)(47-48)(47-84)(48-49)(49-50)(50-52)(51-53)(51-61)(52-84)(53-85)(54-55)(54-85)(55-61)(56-59)(56-86)(57-60)(57-86)(58-63)(58-87)(59-62)(60-62)(63-66)(64-65)(64-87)(65-66)(67-68)(67-69)(68-76)(69-78)(70-71)(70-72)(71-77)(72-79)(73-74)(73-82)(74-83)(75-80)(75-89)(76-91)(77-92)(78-79)(78-91)(79-92)(80-81)(80-90)(81-93)(81-94)(82-95)(83-96)(84-95)(85-95)(86-96)(87-96)(88-97)(89-97)(91-98)(92-98)(95-98)(96-98)(97-98)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| K-562 | 22 | — | 10.1007/s12011-019-01976-0 | 2019 |
| S180 | 23 | — | 10.1371/journal.pone.0105865 | 2014 |
| L-929 | 27 | — | 10.1371/journal.pone.0105865 | 2014 |
| A549 | 28 | — | 10.1007/s12011-019-01976-0 | 2019 |
| L-929 | 28 | — | 10.1007/s12011-019-01976-0 | 2019 |
| Balb/c 3T3 | 48 | — | 10.1016/j.jinorgbio.2021.11162... | 2022 |
| Vero | 48 | — | 10.1016/j.jinorgbio.2021.11162... | 2022 |
| HEL | 55 | — | 10.1016/j.jinorgbio.2021.11162... | 2022 |
| HaCaT | — | — | 10.1016/j.jinorgbio.2021.11162... | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis revealed that the [Ru(gly)(bipy)(dppb)]PF6 complex (2) inhibited the growth of the tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive...»