Info
| ID | 2204 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "O": 2} |
| Abbreviation | Ru-2 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.O=C([O-])c1ccccc1[O-] |
TUCAN
C35H28N4O3Ru/(1-29)(2-33)(3-40)(4-29)(5-29)(6-37)(7-30)(8-34)(9-30)(10-30)(11-41)(12-31)(13-31)(14-31)(15-43)(16-39)(17-32)(18-35)(19-36)(20-32)(21-44)(22-42)(23-46)(24-38)(25-45)(26-48)(27-47)(28-32)(29-55)(30-56)(31-57)(32-59)(33-35)(33-50)(34-36)(34-51)(35-55)(36-56)(37-48)(37-49)(38-39)(38-57)(39-52)(40-41)(40-50)(41-51)(42-46)(42-62)(43-47)(43-52)(44-45)(44-53)(45-59)(46-48)(47-53)(49-62)(49-63)(50-54)(51-58)(52-60)(53-61)(54-58)(54-64)(55-64)(56-65)(57-66)(58-65)(59-67)(60-61)(60-66)(61-67)(62-69)(63-68)(63-70)(64-71)(65-71)(66-71)(67-71)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 26 | — | 10.1155/2020/8890950 | 2020 |
| A549 | 30 | — | 10.1155/2020/8890950 | 2020 |
| HeLa | 32 | — | 10.1155/2020/8890950 | 2020 |
| MCF-7 | 46 | — | 10.1155/2020/8890950 | 2020 |
| BEAS-2B | 48 | — | 10.1155/2020/8890950 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/...»