Info
| ID | 2203 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 2, "N": 4} |
| Abbreviation | Ru-1 |
| SMILES | O=C([O-])c1ccccc1[O-].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C55H36N4O3Ru/(1-40)(2-41)(3-37)(4-46)(5-39)(6-42)(7-82)(8-68)(9-60)(10-43)(11-47)(12-45)(13-38)(14-53)(15-44)(16-83)(17-49)(18-58)(19-56)(20-50)(21-51)(22-63)(23-64)(24-52)(25-84)(26-48)(27-59)(28-85)(29-61)(30-62)(31-55)(32-66)(33-65)(34-54)(35-57)(36-67)(37-40)(37-71)(38-44)(38-69)(39-40)(39-41)(41-42)(42-71)(43-46)(43-76)(44-72)(45-70)(45-82)(46-48)(47-53)(47-76)(48-53)(49-58)(49-78)(50-51)(50-77)(51-80)(52-74)(52-83)(54-75)(54-84)(55-58)(55-59)(56-59)(56-78)(57-81)(57-85)(60-68)(60-90)(61-62)(61-79)(62-65)(63-64)(63-68)(64-73)(65-66)(66-67)(67-79)(69-70)(69-86)(70-71)(72-74)(72-87)(73-90)(73-91)(74-76)(75-77)(75-78)(77-88)(79-81)(80-81)(80-89)(82-92)(83-93)(84-94)(85-95)(86-87)(86-92)(87-93)(88-89)(88-94)(89-95)(90-96)(91-97)(91-98)(92-99)(93-99)(94-99)(95-99)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 11 | — | 10.1155/2020/8890950 | 2020 |
| HepG2 | 15 | — | 10.1155/2020/8890950 | 2020 |
| HeLa | 20 | — | 10.1155/2020/8890950 | 2020 |
| MCF-7 | 30 | — | 10.1155/2020/8890950 | 2020 |
| BEAS-2B | 54 | — | 10.1155/2020/8890950 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/...»