Info
| ID | 2202 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ru(dmp)2Cl2 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.[Cl-].[Cl-] |
TUCAN
C28H24N4Ru/(1-25)(2-30)(3-25)(4-25)(5-26)(6-29)(7-31)(8-26)(9-34)(10-26)(11-32)(12-33)(13-27)(14-27)(15-27)(16-35)(17-40)(18-37)(19-36)(20-28)(21-38)(22-28)(23-28)(24-39)(25-46)(26-47)(27-50)(28-52)(29-34)(29-41)(30-31)(30-46)(31-41)(32-37)(32-47)(33-35)(33-42)(34-42)(35-50)(36-38)(36-43)(37-43)(38-44)(39-40)(39-44)(40-52)(41-45)(42-48)(43-49)(44-51)(45-48)(45-53)(46-53)(47-54)(48-55)(49-51)(49-54)(50-55)(51-56)(52-56)(53-57)(54-57)(55-57)(56-57)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 1.7e+02 | — | 10.1155/2020/8890950 | 2020 |
| A549 | — | — | 10.1155/2020/8890950 | 2020 |
| HeLa | — | — | 10.1155/2020/8890950 | 2020 |
| MCF-7 | — | — | 10.1155/2020/8890950 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/...»