Info
| ID | 2201 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "P": 1} |
| Abbreviation | 5 |
| SMILES | C1N2CN3CN1CP(C2)C3.C1N2CN3CN1CP(C2)C3.C1N2CN3CN1CP(C2)C3.[Cl-].c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C30H44N11P3Ru/(1-66)(2-47)(3-66)(4-48)(5-67)(6-53)(7-54)(8-67)(9-68)(10-68)(11-69)(12-69)(13-70)(14-70)(15-71)(16-71)(17-72)(18-57)(19-50)(20-72)(21-73)(22-73)(23-74)(24-57)(25-58)(26-58)(27-59)(28-59)(29-60)(30-60)(31-61)(32-61)(33-62)(34-62)(35-74)(36-49)(37-63)(38-63)(39-64)(40-64)(41-45)(42-65)(43-46)(44-65)(45-46)(45-51)(46-52)(47-48)(47-51)(48-53)(49-50)(49-52)(50-54)(51-55)(52-56)(53-84)(54-85)(55-56)(55-84)(56-85)(57-75)(57-77)(58-75)(58-76)(59-76)(59-77)(60-78)(60-80)(61-78)(61-79)(62-79)(62-80)(63-81)(63-82)(64-81)(64-83)(65-82)(65-83)(66-75)(66-86)(67-76)(67-86)(68-77)(68-86)(69-78)(69-87)(70-79)(70-87)(71-80)(71-87)(72-81)(72-88)(73-82)(73-88)(74-83)(74-88)(84-89)(85-89)(86-89)(87-89)(88-89)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPMI-8226 | 82 | — | 10.1039/c7dt02051a | 2017 |
| U266 | 1.2e+02 | — | 10.1039/c7dt02051a | 2017 |
🧬 Cell Death Types (1)
Necroptosis
medium
«The results show that an increase in PI+/Ann-V− (necrotic cells) was observed in compound 4-treated cells, while low or no effect was evidenced with the other Ru complexes in both cell lines (Fig. 2S ...»